HGF protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERBB3	GAB1	ENSGGOP00000037530	ENSGGOP00000000019	Protein kinase domain-containing protein.	GRB2 associated binding protein 1.	0.973
ERBB3	HGF	ENSGGOP00000037530	ENSGGOP00000037940	Protein kinase domain-containing protein.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.921
ERBB3	KDR	ENSGGOP00000037530	ENSGGOP00000012526	Protein kinase domain-containing protein.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.424
ERBB3	MET	ENSGGOP00000037530	ENSGGOP00000041736	Protein kinase domain-containing protein.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.968
ERBB3	MST1R	ENSGGOP00000037530	ENSGGOP00000011976	Protein kinase domain-containing protein.	Macrophage stimulating 1 receptor.	0.678
ERBB3	PIK3CA	ENSGGOP00000037530	ENSGGOP00000009158	Protein kinase domain-containing protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.986
ERBB3	STAT3	ENSGGOP00000037530	ENSGGOP00000020538	Protein kinase domain-containing protein.	Signal transducer and activator of transcription.	0.677
GAB1	ERBB3	ENSGGOP00000000019	ENSGGOP00000037530	GRB2 associated binding protein 1.	Protein kinase domain-containing protein.	0.973
GAB1	HGF	ENSGGOP00000000019	ENSGGOP00000037940	GRB2 associated binding protein 1.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.862
GAB1	KDR	ENSGGOP00000000019	ENSGGOP00000012526	GRB2 associated binding protein 1.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.931
GAB1	MET	ENSGGOP00000000019	ENSGGOP00000041736	GRB2 associated binding protein 1.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.991
GAB1	MST1R	ENSGGOP00000000019	ENSGGOP00000011976	GRB2 associated binding protein 1.	Macrophage stimulating 1 receptor.	0.821
GAB1	PIK3CA	ENSGGOP00000000019	ENSGGOP00000009158	GRB2 associated binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.978
HGF	ERBB3	ENSGGOP00000037940	ENSGGOP00000037530	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Protein kinase domain-containing protein.	0.921
HGF	GAB1	ENSGGOP00000037940	ENSGGOP00000000019	Hepatocyte growth factor; Belongs to the peptidase S1 family.	GRB2 associated binding protein 1.	0.862
HGF	HPN	ENSGGOP00000037940	ENSGGOP00000045395	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Hepsin; Belongs to the peptidase S1 family.	0.875
HGF	KDR	ENSGGOP00000037940	ENSGGOP00000012526	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.825
HGF	MET	ENSGGOP00000037940	ENSGGOP00000041736	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.999
HGF	MST1R	ENSGGOP00000037940	ENSGGOP00000011976	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Macrophage stimulating 1 receptor.	0.958
HGF	PIK3CA	ENSGGOP00000037940	ENSGGOP00000009158	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.823