MET protein (Gorilla gorilla) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Gorilla gorilla

NCBI taxonomy Id: 9593
Other names: G. gorilla, Troglodytes gorilla, gorilla, western gorilla

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	GRB2	ENSGGOP00000017349	ENSGGOP00000005990	Cbl proto-oncogene.	Growth factor receptor bound protein 2.	0.997
CBL	HGF	ENSGGOP00000017349	ENSGGOP00000037940	Cbl proto-oncogene.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.699
CBL	MET	ENSGGOP00000017349	ENSGGOP00000041736	Cbl proto-oncogene.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.995
CBL	PIK3CA	ENSGGOP00000017349	ENSGGOP00000009158	Cbl proto-oncogene.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.970
CBL	SRC	ENSGGOP00000017349	ENSGGOP00000018321	Cbl proto-oncogene.	Tyrosine-protein kinase.	0.974
GAB1	GRB2	ENSGGOP00000000019	ENSGGOP00000005990	GRB2 associated binding protein 1.	Growth factor receptor bound protein 2.	0.999
GAB1	HGF	ENSGGOP00000000019	ENSGGOP00000037940	GRB2 associated binding protein 1.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.862
GAB1	MET	ENSGGOP00000000019	ENSGGOP00000041736	GRB2 associated binding protein 1.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.991
GAB1	PIK3CA	ENSGGOP00000000019	ENSGGOP00000009158	GRB2 associated binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.978
GAB1	SRC	ENSGGOP00000000019	ENSGGOP00000018321	GRB2 associated binding protein 1.	Tyrosine-protein kinase.	0.734
GRB2	CBL	ENSGGOP00000005990	ENSGGOP00000017349	Growth factor receptor bound protein 2.	Cbl proto-oncogene.	0.997
GRB2	GAB1	ENSGGOP00000005990	ENSGGOP00000000019	Growth factor receptor bound protein 2.	GRB2 associated binding protein 1.	0.999
GRB2	HGF	ENSGGOP00000005990	ENSGGOP00000037940	Growth factor receptor bound protein 2.	Hepatocyte growth factor; Belongs to the peptidase S1 family.	0.614
GRB2	MET	ENSGGOP00000005990	ENSGGOP00000041736	Growth factor receptor bound protein 2.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.996
GRB2	PIK3CA	ENSGGOP00000005990	ENSGGOP00000009158	Growth factor receptor bound protein 2.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.957
GRB2	PLXNB1	ENSGGOP00000005990	ENSGGOP00000006110	Growth factor receptor bound protein 2.	Plexin B1.	0.619
GRB2	PLXNB3	ENSGGOP00000005990	ENSGGOP00000039636	Growth factor receptor bound protein 2.	Plexin B3.	0.426
GRB2	PTPN1	ENSGGOP00000005990	ENSGGOP00000006885	Growth factor receptor bound protein 2.	Tyrosine-protein phosphatase non-receptor type.	0.808
GRB2	SRC	ENSGGOP00000005990	ENSGGOP00000018321	Growth factor receptor bound protein 2.	Tyrosine-protein kinase.	0.984
HGF	CBL	ENSGGOP00000037940	ENSGGOP00000017349	Hepatocyte growth factor; Belongs to the peptidase S1 family.	Cbl proto-oncogene.	0.699