SETX protein (Pan paniscus) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

SETX

Senataxin. (2669 aa)

Predicted Functional Partners:

BRCA1

0.926

SCAF8

0.832

SCAF4

0.829

POLR2A

0.829

ALS2

0.777

FUS

0.770

VAPB

0.754

APTX

0.741

ENSPPAP00000034099

0.737

RAMAC

0.737

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALS2	FUS	ENSPPAP00000032436	ENSPPAP00000011810	Alsin Rho guanine nucleotide exchange factor ALS2.	FUS RNA binding protein.	0.666
ALS2	SETX	ENSPPAP00000032436	ENSPPAP00000001052	Alsin Rho guanine nucleotide exchange factor ALS2.	Senataxin.	0.777
ALS2	VAPB	ENSPPAP00000032436	ENSPPAP00000022624	Alsin Rho guanine nucleotide exchange factor ALS2.	VAMP associated protein B and C.	0.745
APTX	SETX	ENSPPAP00000014316	ENSPPAP00000001052	Aprataxin.	Senataxin.	0.741
BRCA1	POLR2A	ENSPPAP00000015702	ENSPPAP00000042348	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.901
BRCA1	SETX	ENSPPAP00000015702	ENSPPAP00000001052	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Senataxin.	0.926
ENSPPAP00000034099	SETX	ENSPPAP00000034099	ENSPPAP00000001052	Uncharacterized protein.	Senataxin.	0.737
FUS	ALS2	ENSPPAP00000011810	ENSPPAP00000032436	FUS RNA binding protein.	Alsin Rho guanine nucleotide exchange factor ALS2.	0.666
FUS	POLR2A	ENSPPAP00000011810	ENSPPAP00000042348	FUS RNA binding protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.551
FUS	SETX	ENSPPAP00000011810	ENSPPAP00000001052	FUS RNA binding protein.	Senataxin.	0.770
FUS	VAPB	ENSPPAP00000011810	ENSPPAP00000022624	FUS RNA binding protein.	VAMP associated protein B and C.	0.721
POLR2A	BRCA1	ENSPPAP00000042348	ENSPPAP00000015702	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.901
POLR2A	FUS	ENSPPAP00000042348	ENSPPAP00000011810	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	FUS RNA binding protein.	0.551
POLR2A	SCAF4	ENSPPAP00000042348	ENSPPAP00000010702	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	SR-related CTD associated factor 4.	0.801
POLR2A	SCAF8	ENSPPAP00000042348	ENSPPAP00000034071	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	SR-related CTD associated factor 8.	0.801
POLR2A	SETX	ENSPPAP00000042348	ENSPPAP00000001052	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Senataxin.	0.829
RAMAC	SETX	ENSPPAP00000039187	ENSPPAP00000001052	RNA guanine-7 methyltransferase activating subunit like (pseudogene).	Senataxin.	0.737
SCAF4	POLR2A	ENSPPAP00000010702	ENSPPAP00000042348	SR-related CTD associated factor 4.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.801
SCAF4	SETX	ENSPPAP00000010702	ENSPPAP00000001052	SR-related CTD associated factor 4.	Senataxin.	0.829
SCAF8	POLR2A	ENSPPAP00000034071	ENSPPAP00000042348	SR-related CTD associated factor 8.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.801