AFG3L2 protein (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

AFG3L2

AFG3 like matrix AAA peptidase subunit 2. (797 aa)

Predicted Functional Partners:

SPG7

0.931

TIMMDC1

0.924

ENSPPAP00000003907

0.920

PHB2

0.913

MRPL32

0.874

SMDT1

0.835

ATP6

0.833

PMPCB

0.822

OMA1

0.800

PHB

0.790

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFG3L2	ATP6	ENSPPAP00000001458	ENSPPAP00000000006	AFG3 like matrix AAA peptidase subunit 2.	ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]	0.833
AFG3L2	ENSPPAP00000003907	ENSPPAP00000001458	ENSPPAP00000003907	AFG3 like matrix AAA peptidase subunit 2.	Uncharacterized protein.	0.920
AFG3L2	MRPL32	ENSPPAP00000001458	ENSPPAP00000032797	AFG3 like matrix AAA peptidase subunit 2.	Mitochondrial ribosomal protein L32.	0.874
AFG3L2	OMA1	ENSPPAP00000001458	ENSPPAP00000003074	AFG3 like matrix AAA peptidase subunit 2.	OMA1 zinc metallopeptidase.	0.800
AFG3L2	PHB	ENSPPAP00000001458	ENSPPAP00000007416	AFG3 like matrix AAA peptidase subunit 2.	Prohibitin.	0.790
AFG3L2	PHB2	ENSPPAP00000001458	ENSPPAP00000028255	AFG3 like matrix AAA peptidase subunit 2.	Prohibitin.	0.913
AFG3L2	PMPCB	ENSPPAP00000001458	ENSPPAP00000035221	AFG3 like matrix AAA peptidase subunit 2.	Peptidase, mitochondrial processing beta subunit; Belongs to the peptidase M16 family.	0.822
AFG3L2	SMDT1	ENSPPAP00000001458	ENSPPAP00000026387	AFG3 like matrix AAA peptidase subunit 2.	Single-pass membrane protein with aspartate rich tail 1.	0.835
AFG3L2	SPG7	ENSPPAP00000001458	ENSPPAP00000015347	AFG3 like matrix AAA peptidase subunit 2.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.931
AFG3L2	TIMMDC1	ENSPPAP00000001458	ENSPPAP00000008328	AFG3 like matrix AAA peptidase subunit 2.	Translocase of inner mitochondrial membrane domain containing 1.	0.924
ATP6	AFG3L2	ENSPPAP00000000006	ENSPPAP00000001458	ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]	AFG3 like matrix AAA peptidase subunit 2.	0.833
ATP6	MRPL32	ENSPPAP00000000006	ENSPPAP00000032797	ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]	Mitochondrial ribosomal protein L32.	0.680
ATP6	SPG7	ENSPPAP00000000006	ENSPPAP00000015347	ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]	SPG7 matrix AAA peptidase subunit, paraplegin.	0.644
ENSPPAP00000003907	AFG3L2	ENSPPAP00000003907	ENSPPAP00000001458	Uncharacterized protein.	AFG3 like matrix AAA peptidase subunit 2.	0.920
ENSPPAP00000003907	PHB2	ENSPPAP00000003907	ENSPPAP00000028255	Uncharacterized protein.	Prohibitin.	0.761
ENSPPAP00000003907	PMPCB	ENSPPAP00000003907	ENSPPAP00000035221	Uncharacterized protein.	Peptidase, mitochondrial processing beta subunit; Belongs to the peptidase M16 family.	0.750
ENSPPAP00000003907	SMDT1	ENSPPAP00000003907	ENSPPAP00000026387	Uncharacterized protein.	Single-pass membrane protein with aspartate rich tail 1.	0.617
ENSPPAP00000003907	SPG7	ENSPPAP00000003907	ENSPPAP00000015347	Uncharacterized protein.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.474
ENSPPAP00000003907	TIMMDC1	ENSPPAP00000003907	ENSPPAP00000008328	Uncharacterized protein.	Translocase of inner mitochondrial membrane domain containing 1.	0.962
MRPL32	AFG3L2	ENSPPAP00000032797	ENSPPAP00000001458	Mitochondrial ribosomal protein L32.	AFG3 like matrix AAA peptidase subunit 2.	0.874