STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRYBA1Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)    
Predicted Functional Partners:
LOC100973228
SHSP domain-containing protein; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
   
 
 0.900
GNAT2
G protein subunit alpha transducin 2.
   
  
 0.847
ROM1
Retinal outer segment membrane protein 1.
   
  
 0.842
BEST1
Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.
   
  
 0.828
SLC24A1
Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
   
  
 0.827
PDE6C
Phosphodiesterase.
   
  
 0.826
CRYBB1
Crystallin beta B1; Belongs to the beta/gamma-crystallin family.
  
 
0.794
CRYAB
Crystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
   
 
 0.763
ABCA4
ATP binding cassette subfamily A member 4.
   
  
 0.748
GJA8
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
      
 0.696
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.