Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ZNF648Zinc finger protein 648. (568 aa)    
Predicted Functional Partners:
EZH2
Enhancer of zeste 2 polycomb repressive complex 2 subunit.
   
  0.602
EZH1
Enhancer of zeste 1 polycomb repressive complex 2 subunit.
   
  0.602
SUZ12
VEFS-Box domain-containing protein.
    
 0.587
ASXL2
Uncharacterized protein.
   
  0.587
CBX8
Chromobox 8.
    
  0.565
RING1
E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...]
   
  0.563
TRIM37
Tripartite motif containing 37.
   
  0.561
ZNF792
Zinc finger protein 792.
  
 
 
0.560
ASXL3
ASXL transcriptional regulator 3.
    
  0.560
ASXL1
ASXL transcriptional regulator 1.
    
  0.560
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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