STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN4Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (912 aa)    
Predicted Functional Partners:
GRIN2A
Glutamate ionotropic receptor NMDA type subunit 2A.
    
 
 0.943
PTS
6-pyruvoyl tetrahydrobiopterin synthase.
    
 
 0.679
MAPK12
Mitogen-activated protein kinase.
    
 0.670
TICAM2
TIR domain-containing adaptor molecule 2.
   
 
  0.589
MECP2
Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
   
 
  0.589
TAAR1
Trace amine associated receptor 1; Belongs to the G-protein coupled receptor 1 family.
      
 0.563
GRB2
Growth factor receptor bound protein 2.
   
 0.562
GRID2
Glutamate ionotropic receptor delta type subunit 2.
    
 
 0.512
HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]
    
 0.496
MAPK11
Mitogen-activated protein kinase.
    
 0.470
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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