Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
NKX2-1Uncharacterized protein. (126 aa)    
Predicted Functional Partners:
PAX8
Paired box 8.
   
 
 0.821
SFTA3
Surfactant associated 3.
   
  
 0.818
SFTPC
Surfactant protein C.
   
 
 0.778
SFTPB
Surfactant protein B.
   
 
 0.755
CREBBP
CREB binding protein.
    
 
 0.740
TSHR
Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
      
 0.740
FOXA2
Fork-head domain-containing protein.
   
 
 0.707
TG
Thyroglobulin.
      
 0.680
KRT7
Keratin 7; Belongs to the intermediate filament family.
    
 
 0.629
NAPSA
Napsin A aspartic peptidase; Belongs to the peptidase A1 family.
      
 0.627
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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