AMH protein (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AMH

TGF_BETA_2 domain-containing protein. (408 aa)

Predicted Functional Partners:

AMHR2

0.857

LIN54

0.780

GPR61

0.684

GDF9

0.628

BMP15

0.626

SHBG

0.618

ST8SIA2

0.610

WNT4

0.574

DMRT1

0.567

WT1

0.520

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMH	AMHR2	ENSPPAP00000001989	ENSPPAP00000007747	TGF_BETA_2 domain-containing protein.	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	0.857
AMH	BMP15	ENSPPAP00000001989	ENSPPAP00000001156	TGF_BETA_2 domain-containing protein.	Bone morphogenetic protein 15.	0.626
AMH	DMRT1	ENSPPAP00000001989	ENSPPAP00000027525	TGF_BETA_2 domain-containing protein.	Doublesex and mab-3 related transcription factor 1.	0.567
AMH	GDF9	ENSPPAP00000001989	ENSPPAP00000024835	TGF_BETA_2 domain-containing protein.	Growth differentiation factor 9.	0.628
AMH	GPR61	ENSPPAP00000001989	ENSPPAP00000000977	TGF_BETA_2 domain-containing protein.	G protein-coupled receptor 61; Belongs to the G-protein coupled receptor 1 family.	0.684
AMH	LIN54	ENSPPAP00000001989	ENSPPAP00000040295	TGF_BETA_2 domain-containing protein.	Lin-54 DREAM MuvB core complex component.	0.780
AMH	SHBG	ENSPPAP00000001989	ENSPPAP00000035644	TGF_BETA_2 domain-containing protein.	Sex hormone binding globulin.	0.618
AMH	ST8SIA2	ENSPPAP00000001989	ENSPPAP00000040484	TGF_BETA_2 domain-containing protein.	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; Belongs to the glycosyltransferase 29 family.	0.610
AMH	WNT4	ENSPPAP00000001989	ENSPPAP00000002121	TGF_BETA_2 domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.574
AMH	WT1	ENSPPAP00000001989	ENSPPAP00000021187	TGF_BETA_2 domain-containing protein.	Uncharacterized protein.	0.520
AMHR2	AMH	ENSPPAP00000007747	ENSPPAP00000001989	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	TGF_BETA_2 domain-containing protein.	0.857
AMHR2	BMP15	ENSPPAP00000007747	ENSPPAP00000001156	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	Bone morphogenetic protein 15.	0.621
AMHR2	DMRT1	ENSPPAP00000007747	ENSPPAP00000027525	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	Doublesex and mab-3 related transcription factor 1.	0.486
AMHR2	GDF9	ENSPPAP00000007747	ENSPPAP00000024835	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	Growth differentiation factor 9.	0.639
AMHR2	GPR61	ENSPPAP00000007747	ENSPPAP00000000977	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	G protein-coupled receptor 61; Belongs to the G-protein coupled receptor 1 family.	0.836
AMHR2	WNT4	ENSPPAP00000007747	ENSPPAP00000002121	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.443
BMP15	AMH	ENSPPAP00000001156	ENSPPAP00000001989	Bone morphogenetic protein 15.	TGF_BETA_2 domain-containing protein.	0.626
BMP15	AMHR2	ENSPPAP00000001156	ENSPPAP00000007747	Bone morphogenetic protein 15.	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	0.621
BMP15	GDF9	ENSPPAP00000001156	ENSPPAP00000024835	Bone morphogenetic protein 15.	Growth differentiation factor 9.	0.837
DMRT1	AMH	ENSPPAP00000027525	ENSPPAP00000001989	Doublesex and mab-3 related transcription factor 1.	TGF_BETA_2 domain-containing protein.	0.567