Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RAB12RAB12, member RAS oncogene family. (212 aa)    
Predicted Functional Partners:
GDI1
Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.
    
 0.896
CHM
Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.
    
 0.891
DENND3
DENN domain containing 3.
    
 0.878
LRRK2
Leucine rich repeat kinase 2.
   
 0.829
ENSPPAP00000007558
Uncharacterized protein.
    
 0.783
GDI2
Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.
    
 0.783
RHOBTB3
Rho related BTB domain containing 3.
   
 0.689
ARHGAP27
Rho GTPase activating protein 27.
    
 0.684
RILPL1
Rab interacting lysosomal protein like 1.
    
 0.679
LRRTM1
Leucine rich repeat transmembrane neuronal 1.
    
  0.642
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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