STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC18A2Solute carrier family 18 member A2. (514 aa)    
Predicted Functional Partners:
SNCA
Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...]
     
 0.960
SLC32A1
Solute carrier family 32 member 1.
     
 0.944
SLC17A6
Solute carrier family 17 member 6.
     
 0.943
SLC17A8
Solute carrier family 17 member 8.
     
 0.936
SLC17A7
Solute carrier family 17 member 7.
     
 0.935
SLC18A3
Solute carrier family 18 member A3.
  
  
0.902
SLC18A1
Solute carrier family 18 member A1.
  
  
 
0.901
VAMP2
V-SNARE coiled-coil homology domain-containing protein.
   
 
 0.866
SYT1
Synaptotagmin 1.
     
 0.862
RAB3A
RAB3A, member RAS oncogene family.
     
 0.839
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.