H3-4 protein (Pan paniscus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

H3-4

Histone cluster 3 H3. (136 aa)

Predicted Functional Partners:

CBX5

0.995

UHRF1

0.989

DNMT3A

0.983

KDM4A

0.980

DNMT3L

0.980

KAT2B

0.977

KAT6A

0.975

WDR5

0.974

DNMT3B

0.974

H3-3A

0.973

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBX5	DNMT3A	ENSPPAP00000010215	ENSPPAP00000029896	Chromobox 5.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.711
CBX5	DNMT3B	ENSPPAP00000010215	ENSPPAP00000022800	Chromobox 5.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.853
CBX5	H3-3A	ENSPPAP00000010215	ENSPPAP00000000859	Chromobox 5.	Histone H3; Belongs to the histone H3 family.	0.874
CBX5	H3-4	ENSPPAP00000010215	ENSPPAP00000004803	Chromobox 5.	Histone cluster 3 H3.	0.995
CBX5	UHRF1	ENSPPAP00000010215	ENSPPAP00000027447	Chromobox 5.	Ubiquitin like with PHD and ring finger domains 1.	0.438
DNMT3A	CBX5	ENSPPAP00000029896	ENSPPAP00000010215	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Chromobox 5.	0.711
DNMT3A	DNMT3B	ENSPPAP00000029896	ENSPPAP00000022800	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.997
DNMT3A	DNMT3L	ENSPPAP00000029896	ENSPPAP00000038460	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	PHD-type domain-containing protein.	0.999
DNMT3A	H3-3A	ENSPPAP00000029896	ENSPPAP00000000859	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H3; Belongs to the histone H3 family.	0.897
DNMT3A	H3-4	ENSPPAP00000029896	ENSPPAP00000004803	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone cluster 3 H3.	0.983
DNMT3A	UHRF1	ENSPPAP00000029896	ENSPPAP00000027447	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Ubiquitin like with PHD and ring finger domains 1.	0.826
DNMT3A	WDR5	ENSPPAP00000029896	ENSPPAP00000014928	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	WD repeat domain 5.	0.458
DNMT3B	CBX5	ENSPPAP00000022800	ENSPPAP00000010215	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Chromobox 5.	0.853
DNMT3B	DNMT3A	ENSPPAP00000022800	ENSPPAP00000029896	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.997
DNMT3B	DNMT3L	ENSPPAP00000022800	ENSPPAP00000038460	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	PHD-type domain-containing protein.	0.998
DNMT3B	H3-3A	ENSPPAP00000022800	ENSPPAP00000000859	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone H3; Belongs to the histone H3 family.	0.708
DNMT3B	H3-4	ENSPPAP00000022800	ENSPPAP00000004803	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Histone cluster 3 H3.	0.974
DNMT3B	UHRF1	ENSPPAP00000022800	ENSPPAP00000027447	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Ubiquitin like with PHD and ring finger domains 1.	0.824
DNMT3B	WDR5	ENSPPAP00000022800	ENSPPAP00000014928	DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	WD repeat domain 5.	0.409
DNMT3L	DNMT3A	ENSPPAP00000038460	ENSPPAP00000029896	PHD-type domain-containing protein.	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.999