KNTC1 protein (Pan paniscus) - STRING interaction network

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Score

KNTC1

Kinetochore associated 1. (2208 aa)

Predicted Functional Partners:

ZW10

0.999

ZWILCH

0.997

BRCA1

0.937

BUB1B

0.914

ZWINT

0.897

ASPM

0.875

KIF11

0.871

SMC2

0.806

BUB1

0.781

ESPL1

0.776

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPM	BRCA1	ENSPPAP00000039768	ENSPPAP00000015702	Abnormal spindle microtubule assembly.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.676
ASPM	BUB1	ENSPPAP00000039768	ENSPPAP00000032792	Abnormal spindle microtubule assembly.	BUB1 mitotic checkpoint serine/threonine kinase.	0.956
ASPM	BUB1B	ENSPPAP00000039768	ENSPPAP00000043094	Abnormal spindle microtubule assembly.	BUB1 mitotic checkpoint serine/threonine kinase B.	0.958
ASPM	ESPL1	ENSPPAP00000039768	ENSPPAP00000039582	Abnormal spindle microtubule assembly.	Extra spindle pole bodies like 1, separase.	0.899
ASPM	KIF11	ENSPPAP00000039768	ENSPPAP00000041002	Abnormal spindle microtubule assembly.	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.970
ASPM	KNTC1	ENSPPAP00000039768	ENSPPAP00000007204	Abnormal spindle microtubule assembly.	Kinetochore associated 1.	0.875
ASPM	SMC2	ENSPPAP00000039768	ENSPPAP00000002537	Abnormal spindle microtubule assembly.	Structural maintenance of chromosomes protein.	0.820
ASPM	ZWINT	ENSPPAP00000039768	ENSPPAP00000032025	Abnormal spindle microtubule assembly.	ZW10 interacting kinetochore protein.	0.453
BRCA1	ASPM	ENSPPAP00000015702	ENSPPAP00000039768	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Abnormal spindle microtubule assembly.	0.676
BRCA1	BUB1B	ENSPPAP00000015702	ENSPPAP00000043094	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BUB1 mitotic checkpoint serine/threonine kinase B.	0.400
BRCA1	KNTC1	ENSPPAP00000015702	ENSPPAP00000007204	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Kinetochore associated 1.	0.937
BRCA1	SMC2	ENSPPAP00000015702	ENSPPAP00000002537	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Structural maintenance of chromosomes protein.	0.589
BUB1	ASPM	ENSPPAP00000032792	ENSPPAP00000039768	BUB1 mitotic checkpoint serine/threonine kinase.	Abnormal spindle microtubule assembly.	0.956
BUB1	BUB1B	ENSPPAP00000032792	ENSPPAP00000043094	BUB1 mitotic checkpoint serine/threonine kinase.	BUB1 mitotic checkpoint serine/threonine kinase B.	0.998
BUB1	ESPL1	ENSPPAP00000032792	ENSPPAP00000039582	BUB1 mitotic checkpoint serine/threonine kinase.	Extra spindle pole bodies like 1, separase.	0.981
BUB1	KIF11	ENSPPAP00000032792	ENSPPAP00000041002	BUB1 mitotic checkpoint serine/threonine kinase.	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.979
BUB1	KNTC1	ENSPPAP00000032792	ENSPPAP00000007204	BUB1 mitotic checkpoint serine/threonine kinase.	Kinetochore associated 1.	0.781
BUB1	SMC2	ENSPPAP00000032792	ENSPPAP00000002537	BUB1 mitotic checkpoint serine/threonine kinase.	Structural maintenance of chromosomes protein.	0.651
BUB1	ZW10	ENSPPAP00000032792	ENSPPAP00000016688	BUB1 mitotic checkpoint serine/threonine kinase.	Zw10 kinetochore protein.	0.795
BUB1	ZWILCH	ENSPPAP00000032792	ENSPPAP00000021349	BUB1 mitotic checkpoint serine/threonine kinase.	Zwilch kinetochore protein.	0.881