KNTC1 protein (Pan paniscus) - STRING interaction network

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Score

KNTC1

Kinetochore associated 1. (2208 aa)

Predicted Functional Partners:

ZW10

0.999

ZWILCH

0.999

KIF11

0.906

BUB1B

0.885

ASPM

0.884

BUB1

0.862

ESPL1

0.852

SMC2

0.847

BRCA1

0.834

TTK

0.821

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPM	BRCA1	ENSPPAP00000039768	ENSPPAP00000015702	Abnormal spindle microtubule assembly.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.568
ASPM	BUB1	ENSPPAP00000039768	ENSPPAP00000032792	Abnormal spindle microtubule assembly.	BUB1 mitotic checkpoint serine/threonine kinase.	0.939
ASPM	BUB1B	ENSPPAP00000039768	ENSPPAP00000043094	Abnormal spindle microtubule assembly.	BUB1 mitotic checkpoint serine/threonine kinase B.	0.924
ASPM	ESPL1	ENSPPAP00000039768	ENSPPAP00000039582	Abnormal spindle microtubule assembly.	Extra spindle pole bodies like 1, separase.	0.847
ASPM	KIF11	ENSPPAP00000039768	ENSPPAP00000041002	Abnormal spindle microtubule assembly.	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.931
ASPM	KNTC1	ENSPPAP00000039768	ENSPPAP00000007204	Abnormal spindle microtubule assembly.	Kinetochore associated 1.	0.884
ASPM	SMC2	ENSPPAP00000039768	ENSPPAP00000002537	Abnormal spindle microtubule assembly.	Structural maintenance of chromosomes protein.	0.855
ASPM	TTK	ENSPPAP00000039768	ENSPPAP00000040670	Abnormal spindle microtubule assembly.	TTK protein kinase.	0.906
BRCA1	ASPM	ENSPPAP00000015702	ENSPPAP00000039768	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Abnormal spindle microtubule assembly.	0.568
BRCA1	BUB1	ENSPPAP00000015702	ENSPPAP00000032792	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BUB1 mitotic checkpoint serine/threonine kinase.	0.590
BRCA1	BUB1B	ENSPPAP00000015702	ENSPPAP00000043094	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BUB1 mitotic checkpoint serine/threonine kinase B.	0.467
BRCA1	KNTC1	ENSPPAP00000015702	ENSPPAP00000007204	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Kinetochore associated 1.	0.834
BRCA1	SMC2	ENSPPAP00000015702	ENSPPAP00000002537	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Structural maintenance of chromosomes protein.	0.600
BRCA1	TTK	ENSPPAP00000015702	ENSPPAP00000040670	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	TTK protein kinase.	0.526
BUB1	ASPM	ENSPPAP00000032792	ENSPPAP00000039768	BUB1 mitotic checkpoint serine/threonine kinase.	Abnormal spindle microtubule assembly.	0.939
BUB1	BRCA1	ENSPPAP00000032792	ENSPPAP00000015702	BUB1 mitotic checkpoint serine/threonine kinase.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.590
BUB1	BUB1B	ENSPPAP00000032792	ENSPPAP00000043094	BUB1 mitotic checkpoint serine/threonine kinase.	BUB1 mitotic checkpoint serine/threonine kinase B.	0.999
BUB1	ESPL1	ENSPPAP00000032792	ENSPPAP00000039582	BUB1 mitotic checkpoint serine/threonine kinase.	Extra spindle pole bodies like 1, separase.	0.973
BUB1	KIF11	ENSPPAP00000032792	ENSPPAP00000041002	BUB1 mitotic checkpoint serine/threonine kinase.	Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.949
BUB1	KNTC1	ENSPPAP00000032792	ENSPPAP00000007204	BUB1 mitotic checkpoint serine/threonine kinase.	Kinetochore associated 1.	0.862