STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1743 aa)    
Predicted Functional Partners:
TRIP12
Thyroid hormone receptor interactor 12.
   
 0.956
UBE2A
Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.790
UBE2B
Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.790
ZZZ3
Uncharacterized protein.
   
    0.783
HUWE1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
   
 
 0.780
VBP1
Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family.
      
 0.776
UBR4
Ubiquitin protein ligase E3 component n-recognin 4.
   
  
 0.746
UBR5
Ubiquitin protein ligase E3 component n-recognin 5.
   
  
 0.721
LTN1
Listerin E3 ubiquitin protein ligase 1.
   
 0.720
RECQL4
RecQ like helicase 4.
   
 
 0.713
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.