XBP1 protein (Pan paniscus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

XBP1

BZIP domain-containing protein. (380 aa)

Predicted Functional Partners:

ERN1

0.986

DDIT3

0.976

ATF6

0.968

TBP

0.920

TBPL2

0.920

TBPL1

0.917

EDEM1

0.865

SEC61B

0.851

SEC61A1

0.850

HSPA5

0.835

Your Current Organism:

Pan paniscus

NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF6	DDIT3	ENSPPAP00000006576	ENSPPAP00000022208	Activating transcription factor 6.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.989
ATF6	EDEM1	ENSPPAP00000006576	ENSPPAP00000010495	Activating transcription factor 6.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.701
ATF6	ERN1	ENSPPAP00000006576	ENSPPAP00000015883	Activating transcription factor 6.	Endoplasmic reticulum to nucleus signaling 1.	0.785
ATF6	HSPA5	ENSPPAP00000006576	ENSPPAP00000040660	Activating transcription factor 6.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.999
ATF6	XBP1	ENSPPAP00000006576	ENSPPAP00000009838	Activating transcription factor 6.	BZIP domain-containing protein.	0.968
DDIT3	ATF6	ENSPPAP00000022208	ENSPPAP00000006576	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Activating transcription factor 6.	0.989
DDIT3	EDEM1	ENSPPAP00000022208	ENSPPAP00000010495	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.459
DDIT3	ERN1	ENSPPAP00000022208	ENSPPAP00000015883	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Endoplasmic reticulum to nucleus signaling 1.	0.698
DDIT3	HSPA5	ENSPPAP00000022208	ENSPPAP00000040660	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.714
DDIT3	XBP1	ENSPPAP00000022208	ENSPPAP00000009838	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	BZIP domain-containing protein.	0.976
EDEM1	ATF6	ENSPPAP00000010495	ENSPPAP00000006576	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Activating transcription factor 6.	0.701
EDEM1	DDIT3	ENSPPAP00000010495	ENSPPAP00000022208	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.459
EDEM1	ERN1	ENSPPAP00000010495	ENSPPAP00000015883	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Endoplasmic reticulum to nucleus signaling 1.	0.682
EDEM1	HSPA5	ENSPPAP00000010495	ENSPPAP00000040660	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.739
EDEM1	SEC61A1	ENSPPAP00000010495	ENSPPAP00000004795	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	SEC61 translocon alpha 1 subunit.	0.470
EDEM1	SEC61B	ENSPPAP00000010495	ENSPPAP00000002001	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.531
EDEM1	XBP1	ENSPPAP00000010495	ENSPPAP00000009838	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	BZIP domain-containing protein.	0.865
ERN1	ATF6	ENSPPAP00000015883	ENSPPAP00000006576	Endoplasmic reticulum to nucleus signaling 1.	Activating transcription factor 6.	0.785
ERN1	DDIT3	ENSPPAP00000015883	ENSPPAP00000022208	Endoplasmic reticulum to nucleus signaling 1.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.698
ERN1	EDEM1	ENSPPAP00000015883	ENSPPAP00000010495	Endoplasmic reticulum to nucleus signaling 1.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.682