STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)    
Predicted Functional Partners:
S100A8
Protein S100; Belongs to the S-100 family.
   
0.994
S100A9
Protein S100; Belongs to the S-100 family.
  
 
0.962
AGER
Advanced glycosylation end-product specific receptor.
   
 0.946
TLR4
Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]
   
 0.796
S100A7
Protein S100; Belongs to the S-100 family.
   
 0.770
SLC11A1
Solute carrier family 11 member 1.
   
 
 0.733
KRT77
Keratin 77; Belongs to the intermediate filament family.
   
 0.671
CAMP
Cathelicidin antimicrobial peptide.
   
 
 0.646
KLK5
Kallikrein related peptidase 5; Belongs to the peptidase S1 family.
    
 0.641
SERPINB13
Serpin family B member 13; Belongs to the serpin family.
   
 0.634
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.