STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (551 aa)    
Predicted Functional Partners:
NOD1
Nucleotide binding oligomerization domain containing 1.
   
 0.999
XIAP
X-linked inhibitor of apoptosis.
   
 0.999
NOD2
Nucleotide binding oligomerization domain containing 2.
   
 0.999
NGFR
Nerve growth factor receptor.
    
 0.993
BIRC2
Baculoviral IAP repeat containing 2.
   
 0.989
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.988
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
   
 0.987
TAB3
TGF-beta activated kinase 1 (MAP3K7) binding protein 3.
    
 0.980
TRAF3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.978
TAB2
TGF-beta activated kinase 1 (MAP3K7) binding protein 2.
    
 0.978
Your Current Organism:
Pan paniscus
NCBI taxonomy Id: 9597
Other names: P. paniscus, bonobo, pygmy chimpanzee
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.