Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PPIEPeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (314 aa)    
Predicted Functional Partners:
AQR
RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
    
 0.995
CRNKL1
Crooked neck pre-mRNA splicing factor 1.
   
 0.993
XAB2
XPA binding protein 2.
   
 0.990
RBM22
RNA binding motif protein 22.
   
 0.987
BUD31
BUD31 isoform 1.
   
  0.986
PRPF19
PRP19/PSO4 pre-mRNA processing factor 19 homolog.
   
 0.986
ZNF830
Zinc finger protein 830.
    
 0.985
ISY1
ISY1 splicing factor homolog.
   
  0.972
SYF2
SYF2 homolog, RNA splicing factor.
    
 0.953
SNW1
SNW domain containing 1.
   
 0.923
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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