STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMSB4X-2Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (54 aa)    
Predicted Functional Partners:
ACTB
Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.
   
 0.918
PRKX
Protein kinase, X-linked; Belongs to the protein kinase superfamily.
   
  
 0.691
PRKY
Serine/threonine-protein kinase PRKX.
   
  
 0.689
TBL1X
Transducin (Beta)-like 1X-linked.
   
  
 0.667
ZFX
Zinc finger protein X-linked.
   
  
 0.663
PFN4
Profilin; Belongs to the profilin family.
   
 
 0.631
PFN3
Profilin; Belongs to the profilin family.
   
 
 0.631
USP9X
Ubiquitin specific peptidase 9, X-linked; Belongs to the peptidase C19 family.
   
  
 0.622
LOC737606
T0172536 isoform 1.
    
 
 0.608
ILK
Integrin-linked kinase.
    
 
 0.602
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.