STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDC20Cell division cycle 20 homolog. (499 aa)    
Predicted Functional Partners:
MAD2L1
MAD2 mitotic arrest deficient-like 1.
   
 0.999
CCNB1
CCNB1 isoform 1; Belongs to the cyclin family.
   
 0.999
FBXO5
F-box protein 5.
   
 0.999
CCNB2
CCNB2 isoform 1; Belongs to the cyclin family.
   
 0.997
BUB1B
BUB1B-PAK6 isoform 4.
   
 0.996
BUB1
BUB1 isoform 1.
   
 0.994
PLK1
Serine/threonine-protein kinase PLK.
   
 0.994
CDC23
Cell division cycle 23 homolog.
   
 0.993
PTTG1
Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...]
   
 0.992
ANAPC2
Anaphase promoting complex subunit 2; Belongs to the cullin family.
   
 0.992
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.