| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP2A1 | AP2A2 | ENSPTRP00000068470 | ENSPTRP00000005552 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | AP2A2 isoform 4. | 0.999 |
| AP2A1 | AP2S1 | ENSPTRP00000068470 | ENSPTRP00000088940 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | 0.999 |
| AP2A1 | CLTB | ENSPTRP00000068470 | ENSPTRP00000081187 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | 0.981 |
| AP2A1 | EGFR | ENSPTRP00000068470 | ENSPTRP00000069741 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Receptor protein-tyrosine kinase. | 0.937 |
| AP2A1 | EPN1 | ENSPTRP00000068470 | ENSPTRP00000019816 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | EPN1 isoform 5. | 0.911 |
| AP2A1 | EPN2 | ENSPTRP00000068470 | ENSPTRP00000068433 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | EPN2 isoform 5. | 0.948 |
| AP2A1 | EPS15 | ENSPTRP00000068470 | ENSPTRP00000001250 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Epidermal growth factor receptor pathway substrate 15. | 0.995 |
| AP2A1 | EPS15L1 | ENSPTRP00000068470 | ENSPTRP00000018168 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Epidermal growth factor receptor pathway substrate 15 like 1. | 0.954 |
| AP2A1 | HGS | ENSPTRP00000068470 | ENSPTRP00000016628 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.831 |
| AP2A1 | STON2 | ENSPTRP00000068470 | ENSPTRP00000011219 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | STON2 isoform 1; Belongs to the Stoned B family. | 0.972 |
| AP2A2 | AP2A1 | ENSPTRP00000005552 | ENSPTRP00000068470 | AP2A2 isoform 4. | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] | 0.999 |
| AP2A2 | AP2S1 | ENSPTRP00000005552 | ENSPTRP00000088940 | AP2A2 isoform 4. | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. | 0.999 |
| AP2A2 | CLTB | ENSPTRP00000005552 | ENSPTRP00000081187 | AP2A2 isoform 4. | Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. | 0.974 |
| AP2A2 | EGFR | ENSPTRP00000005552 | ENSPTRP00000069741 | AP2A2 isoform 4. | Receptor protein-tyrosine kinase. | 0.889 |
| AP2A2 | EPN1 | ENSPTRP00000005552 | ENSPTRP00000019816 | AP2A2 isoform 4. | EPN1 isoform 5. | 0.875 |
| AP2A2 | EPN2 | ENSPTRP00000005552 | ENSPTRP00000068433 | AP2A2 isoform 4. | EPN2 isoform 5. | 0.927 |
| AP2A2 | EPS15 | ENSPTRP00000005552 | ENSPTRP00000001250 | AP2A2 isoform 4. | Epidermal growth factor receptor pathway substrate 15. | 0.980 |
| AP2A2 | EPS15L1 | ENSPTRP00000005552 | ENSPTRP00000018168 | AP2A2 isoform 4. | Epidermal growth factor receptor pathway substrate 15 like 1. | 0.922 |
| AP2A2 | HGS | ENSPTRP00000005552 | ENSPTRP00000016628 | AP2A2 isoform 4. | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] | 0.451 |
| AP2A2 | STON2 | ENSPTRP00000005552 | ENSPTRP00000011219 | AP2A2 isoform 4. | STON2 isoform 1; Belongs to the Stoned B family. | 0.938 |
