Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (507 aa)    
Predicted Functional Partners:
BCKDHA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3); Belongs to the BCKDHA family.
 
 0.999
BCKDHB
BCKDHB isoform 1.
 
 0.999
DLD
Dihydrolipoyl dehydrogenase.
 
 0.999
PCCB
Propionyl-CoA carboxylase subunit beta.
  
 
 0.978
IVD
Isovaleryl-CoA dehydrogenase.
  
 0.971
PCCA
Propionyl CoA carboxylase, alpha polypeptide.
  
 0.964
ACADS
Acyl-CoA dehydrogenase, C-2 to C-3 short chain.
  
 0.962
PPM1K
Protein phosphatase, Mg2+/Mn2+ dependent, 1K.
   
 0.960
ACADSB
Acyl-CoA dehydrogenase, short/branched chain.
  
 0.958
ALDH6A1
Aldehyde dehydrogenase 6 family, member A1.
   
 
 0.951
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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