STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHO1Pleckstrin homology domain containing, family O member 1. (409 aa)    
Predicted Functional Partners:
SMURF1
E3 ubiquitin-protein ligase.
    
 
 0.897
CSNK2A2
Casein kinase 2, alpha prime polypeptide; Belongs to the protein kinase superfamily.
    
 
 0.803
PLEK
PLEK isoform 1.
   
  
 0.505
PLEK2
PLEK2 isoform 1.
   
  
 0.483
IFI35
Interferon-induced protein 35.
    
 
 0.482
SMURF2
E3 ubiquitin-protein ligase.
    
 
 0.468
CARMIL1
Capping protein regulator and myosin 1 linker 1.
      
 0.465
NMI
N-myc (And STAT) interactor.
      
 0.463
CSNK2B
LY6G5B isoform 1.
      
 0.459
AKT1
AKT1 isoform 3; Belongs to the protein kinase superfamily.
    
 
 0.426
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.