| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGER | APP | ENSPTRP00000050324 | ENSPTRP00000093932 | Advanced glycosylation end-product specific receptor. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.563 |
| AGER | S100A12 | ENSPTRP00000050324 | ENSPTRP00000002271 | Advanced glycosylation end-product specific receptor. | S100 calcium binding protein A12; Belongs to the S-100 family. | 0.837 |
| AGER | S100A9 | ENSPTRP00000050324 | ENSPTRP00000002268 | Advanced glycosylation end-product specific receptor. | Protein S100; Belongs to the S-100 family. | 0.638 |
| AGER | TLR4 | ENSPTRP00000050324 | ENSPTRP00000036398 | Advanced glycosylation end-product specific receptor. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.404 |
| APP | AGER | ENSPTRP00000093932 | ENSPTRP00000050324 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Advanced glycosylation end-product specific receptor. | 0.563 |
| APP | S100A12 | ENSPTRP00000093932 | ENSPTRP00000002271 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | S100 calcium binding protein A12; Belongs to the S-100 family. | 0.624 |
| APP | S100A9 | ENSPTRP00000093932 | ENSPTRP00000002268 | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Protein S100; Belongs to the S-100 family. | 0.443 |
| CAMP | S100A12 | ENSPTRP00000025671 | ENSPTRP00000002271 | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. | S100 calcium binding protein A12; Belongs to the S-100 family. | 0.634 |
| CAMP | S100A7 | ENSPTRP00000025671 | ENSPTRP00000075915 | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. | Protein S100; Belongs to the S-100 family. | 0.485 |
| CAMP | S100A8 | ENSPTRP00000025671 | ENSPTRP00000002272 | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. | Protein S100; Belongs to the S-100 family. | 0.629 |
| CAMP | S100A9 | ENSPTRP00000025671 | ENSPTRP00000002268 | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. | Protein S100; Belongs to the S-100 family. | 0.621 |
| CAMP | TLR4 | ENSPTRP00000025671 | ENSPTRP00000036398 | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. | Toll-like receptor 4; Belongs to the Toll-like receptor family. | 0.446 |
| CYBA | S100A12 | ENSPTRP00000091520 | ENSPTRP00000002271 | Cytochrome b-245 alpha chain. | S100 calcium binding protein A12; Belongs to the S-100 family. | 0.574 |
| CYBA | S100A8 | ENSPTRP00000091520 | ENSPTRP00000002272 | Cytochrome b-245 alpha chain. | Protein S100; Belongs to the S-100 family. | 0.427 |
| CYBA | S100A9 | ENSPTRP00000091520 | ENSPTRP00000002268 | Cytochrome b-245 alpha chain. | Protein S100; Belongs to the S-100 family. | 0.559 |
| RNASE6 | S100A12 | ENSPTRP00000010358 | ENSPTRP00000002271 | Ribonuclease K6; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. | S100 calcium binding protein A12; Belongs to the S-100 family. | 0.579 |
| S100A12 | AGER | ENSPTRP00000002271 | ENSPTRP00000050324 | S100 calcium binding protein A12; Belongs to the S-100 family. | Advanced glycosylation end-product specific receptor. | 0.837 |
| S100A12 | APP | ENSPTRP00000002271 | ENSPTRP00000093932 | S100 calcium binding protein A12; Belongs to the S-100 family. | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.624 |
| S100A12 | CAMP | ENSPTRP00000002271 | ENSPTRP00000025671 | S100 calcium binding protein A12; Belongs to the S-100 family. | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Belongs to the cathelicidin family. | 0.634 |
| S100A12 | CYBA | ENSPTRP00000002271 | ENSPTRP00000091520 | S100 calcium binding protein A12; Belongs to the S-100 family. | Cytochrome b-245 alpha chain. | 0.574 |
