| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALPL | BGLAP | ENSPTRP00000074293 | ENSPTRP00000002450 | Alkaline phosphatase. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.675 |
| ALPL | BMP2 | ENSPTRP00000074293 | ENSPTRP00000022701 | Alkaline phosphatase. | Bone morphogenetic protein 2. | 0.573 |
| ALPL | COL1A1 | ENSPTRP00000074293 | ENSPTRP00000015952 | Alkaline phosphatase. | Collagen type I alpha 1 chain. | 0.633 |
| ALPL | IBSP | ENSPTRP00000074293 | ENSPTRP00000027934 | Alkaline phosphatase. | Integrin binding sialoprotein. | 0.672 |
| ALPL | RUNX1 | ENSPTRP00000074293 | ENSPTRP00000092866 | Alkaline phosphatase. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.432 |
| ALPL | RUNX2 | ENSPTRP00000074293 | ENSPTRP00000065999 | Alkaline phosphatase. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.734 |
| ALPL | RUNX3 | ENSPTRP00000074293 | ENSPTRP00000000614 | Alkaline phosphatase. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.519 |
| ALPL | SPP1 | ENSPTRP00000074293 | ENSPTRP00000092389 | Alkaline phosphatase. | Secreted phosphoprotein 1. | 0.583 |
| BGLAP | ALPL | ENSPTRP00000002450 | ENSPTRP00000074293 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Alkaline phosphatase. | 0.675 |
| BGLAP | BMP2 | ENSPTRP00000002450 | ENSPTRP00000022701 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Bone morphogenetic protein 2. | 0.650 |
| BGLAP | COL1A1 | ENSPTRP00000002450 | ENSPTRP00000015952 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Collagen type I alpha 1 chain. | 0.601 |
| BGLAP | GGCX | ENSPTRP00000002450 | ENSPTRP00000020816 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Gamma-glutamyl carboxylase. | 0.925 |
| BGLAP | IBSP | ENSPTRP00000002450 | ENSPTRP00000027934 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Integrin binding sialoprotein. | 0.710 |
| BGLAP | MSX2 | ENSPTRP00000002450 | ENSPTRP00000029971 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity); Belongs to the Msh homeobox family. | 0.593 |
| BGLAP | RUNX1 | ENSPTRP00000002450 | ENSPTRP00000092866 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.617 |
| BGLAP | RUNX2 | ENSPTRP00000002450 | ENSPTRP00000065999 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.891 |
| BGLAP | RUNX3 | ENSPTRP00000002450 | ENSPTRP00000000614 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.617 |
| BGLAP | SPP1 | ENSPTRP00000002450 | ENSPTRP00000092389 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | Secreted phosphoprotein 1. | 0.575 |
| BMP2 | ALPL | ENSPTRP00000022701 | ENSPTRP00000074293 | Bone morphogenetic protein 2. | Alkaline phosphatase. | 0.573 |
| BMP2 | BGLAP | ENSPTRP00000022701 | ENSPTRP00000002450 | Bone morphogenetic protein 2. | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. | 0.650 |
