ACKR1 protein (Pan troglodytes) - STRING interaction network

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ACKR1

Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...] (336 aa)

Predicted Functional Partners:

TNFRSF14

0.906

CCL5

0.850

NECTIN1

0.847

CCL2

0.846

CXCL1

0.845

NECTIN2

0.801

CD82

0.792

CXCL5

0.697

HBB

0.692

PPBP

0.683

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACKR1	CCL2	ENSPTRP00000002561	ENSPTRP00000068745	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	C-C motif chemokine.	0.846
ACKR1	CCL5	ENSPTRP00000002561	ENSPTRP00000083031	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	C-C motif chemokine.	0.850
ACKR1	CD82	ENSPTRP00000002561	ENSPTRP00000086638	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	Tetraspanin.	0.792
ACKR1	CXCL1	ENSPTRP00000002561	ENSPTRP00000027773	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	C-X-C motif chemokine.	0.845
ACKR1	CXCL5	ENSPTRP00000002561	ENSPTRP00000027776	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	C-X-C motif chemokine.	0.697
ACKR1	HBB	ENSPTRP00000002561	ENSPTRP00000005700	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues.	0.692
ACKR1	NECTIN1	ENSPTRP00000002561	ENSPTRP00000080196	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	NECTIN1 isoform 1.	0.847
ACKR1	NECTIN2	ENSPTRP00000002561	ENSPTRP00000089575	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	Poliovirus receptor-related 2 (Herpesvirus entry mediator B).	0.801
ACKR1	PPBP	ENSPTRP00000002561	ENSPTRP00000027775	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	C-X-C motif chemokine.	0.683
ACKR1	TNFRSF14	ENSPTRP00000002561	ENSPTRP00000000096	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator).	0.906
CCL2	ACKR1	ENSPTRP00000068745	ENSPTRP00000002561	C-C motif chemokine.	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	0.846
CCL2	CCL5	ENSPTRP00000068745	ENSPTRP00000083031	C-C motif chemokine.	C-C motif chemokine.	0.997
CCL2	CXCL1	ENSPTRP00000068745	ENSPTRP00000027773	C-C motif chemokine.	C-X-C motif chemokine.	0.926
CCL2	CXCL5	ENSPTRP00000068745	ENSPTRP00000027776	C-C motif chemokine.	C-X-C motif chemokine.	0.875
CCL2	PPBP	ENSPTRP00000068745	ENSPTRP00000027775	C-C motif chemokine.	C-X-C motif chemokine.	0.638
CCL5	ACKR1	ENSPTRP00000083031	ENSPTRP00000002561	C-C motif chemokine.	Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]	0.850
CCL5	CCL2	ENSPTRP00000083031	ENSPTRP00000068745	C-C motif chemokine.	C-C motif chemokine.	0.997
CCL5	CXCL1	ENSPTRP00000083031	ENSPTRP00000027773	C-C motif chemokine.	C-X-C motif chemokine.	0.922
CCL5	CXCL5	ENSPTRP00000083031	ENSPTRP00000027776	C-C motif chemokine.	C-X-C motif chemokine.	0.807
CCL5	PPBP	ENSPTRP00000083031	ENSPTRP00000027775	C-C motif chemokine.	C-X-C motif chemokine.	0.993

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