node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCC1 | CYP3A4 | ENSPTRP00000075385 | ENSPTRP00000081767 | ATP binding cassette subfamily C member 1. | Cytochrome P450 family 3 subfamily A member 4. | 0.414 |
ABCC1 | CYP3A5 | ENSPTRP00000075385 | ENSPTRP00000033296 | ATP binding cassette subfamily C member 1. | CYP3A5 isoform 1. | 0.417 |
ABCC1 | FMO3 | ENSPTRP00000075385 | ENSPTRP00000002778 | ATP binding cassette subfamily C member 1. | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] | 0.677 |
ABCC1 | NAT2 | ENSPTRP00000075385 | ENSPTRP00000034297 | ATP binding cassette subfamily C member 1. | N-acetyltransferase 2 (Arylamine N-acetyltransferase); Belongs to the arylamine N-acetyltransferase family. | 0.660 |
ABCC1 | UGT1A5 | ENSPTRP00000075385 | ENSPTRP00000063403 | ATP binding cassette subfamily C member 1. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.500 |
ABCC1 | UGT3A1 | ENSPTRP00000075385 | ENSPTRP00000028795 | ATP binding cassette subfamily C member 1. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.632 |
ABCC1 | UGT3A2 | ENSPTRP00000075385 | ENSPTRP00000075590 | ATP binding cassette subfamily C member 1. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.506 |
CYP2C9 | CYP2D6 | ENSPTRP00000004853 | ENSPTRP00000042793 | Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. | Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] | 0.563 |
CYP2C9 | CYP3A4 | ENSPTRP00000004853 | ENSPTRP00000081767 | Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. | Cytochrome P450 family 3 subfamily A member 4. | 0.960 |
CYP2C9 | CYP3A5 | ENSPTRP00000004853 | ENSPTRP00000033296 | Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. | CYP3A5 isoform 1. | 0.948 |
CYP2C9 | FMO3 | ENSPTRP00000004853 | ENSPTRP00000002778 | Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] | 0.932 |
CYP2C9 | NAT2 | ENSPTRP00000004853 | ENSPTRP00000034297 | Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. | N-acetyltransferase 2 (Arylamine N-acetyltransferase); Belongs to the arylamine N-acetyltransferase family. | 0.489 |
CYP2C9 | UGT1A5 | ENSPTRP00000004853 | ENSPTRP00000063403 | Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.444 |
CYP2D6 | CYP2C9 | ENSPTRP00000042793 | ENSPTRP00000004853 | Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] | Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. | 0.563 |
CYP2D6 | CYP3A4 | ENSPTRP00000042793 | ENSPTRP00000081767 | Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] | Cytochrome P450 family 3 subfamily A member 4. | 0.949 |
CYP2D6 | CYP3A5 | ENSPTRP00000042793 | ENSPTRP00000033296 | Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] | CYP3A5 isoform 1. | 0.505 |
CYP2D6 | FMO3 | ENSPTRP00000042793 | ENSPTRP00000002778 | Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] | 0.940 |
CYP2D6 | NAT2 | ENSPTRP00000042793 | ENSPTRP00000034297 | Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] | N-acetyltransferase 2 (Arylamine N-acetyltransferase); Belongs to the arylamine N-acetyltransferase family. | 0.537 |
CYP3A4 | ABCC1 | ENSPTRP00000081767 | ENSPTRP00000075385 | Cytochrome P450 family 3 subfamily A member 4. | ATP binding cassette subfamily C member 1. | 0.414 |
CYP3A4 | CYP2C9 | ENSPTRP00000081767 | ENSPTRP00000004853 | Cytochrome P450 family 3 subfamily A member 4. | Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. | 0.960 |