STRINGSTRING
FMO3 protein (Pan troglodytes) - STRING interaction network
"FMO3" - Dimethylaniline monooxygenase [N-oxide-forming] 3 in Pan troglodytes
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FMO3Dimethylaniline monooxygenase [N-oxide-forming] 3; Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Acts on TMA to produce TMA-N-oxide (By similarity) (532 aa)    
Predicted Functional Partners:
CYP3A4
Pan troglodytes cytochrome P450, family 3, subfamily A, polypeptide 67 (CYP3A7), mRNA (503 aa)
   
  0.952
CYP2D6
Cytochrome P450 2D6; Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants; Belongs to the cytochrome P450 family (498 aa)
   
  0.943
CYP2C9
Uncharacterized protein; Cytochrome P450, family 2, subfamily C, polypeptide 9 (490 aa)
   
  0.932
DMGDH
Uncharacterized protein; Dimethylglycine dehydrogenase (866 aa)
   
   
  0.705
COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3- polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6 (468 aa)
   
 
  0.629
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial; Uncharacterized protein (335 aa)
   
 
  0.605
HAO2
Uncharacterized protein; Hydroxyacid oxidase 2 (long chain) (350 aa)
   
   
  0.575
CYP3A5
Pan troglodytes cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5), mRNA (502 aa)
   
 
  0.570
NAT2
N-acetyltransferase 2 (Arylamine N-acetyltransferase); Uncharacterized protein ; Belongs to the arylamine N-acetyltransferase family (290 aa)
     
   
  0.560
NR1H4
Uncharacterized protein; Nuclear receptor subfamily 1, group H, member 4 (472 aa)
     
   
  0.493
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, Pan troglodytes, chimpanzee
Server load: low (16%) [HD]