| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADO | CSAD | ENSPTRP00000060555 | ENSPTRP00000083350 | 2-aminoethanethiol (Cysteamine) dioxygenase. | Cysteine sulfinic acid decarboxylase. | 0.941 |
| ADO | FMO3 | ENSPTRP00000060555 | ENSPTRP00000002778 | 2-aminoethanethiol (Cysteamine) dioxygenase. | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] | 0.900 |
| ADO | GAD1 | ENSPTRP00000060555 | ENSPTRP00000021575 | 2-aminoethanethiol (Cysteamine) dioxygenase. | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. | 0.924 |
| ADO | GAD2 | ENSPTRP00000060555 | ENSPTRP00000092080 | 2-aminoethanethiol (Cysteamine) dioxygenase. | Glutamate decarboxylase 2. | 0.919 |
| ADO | GADL1 | ENSPTRP00000060555 | ENSPTRP00000093466 | 2-aminoethanethiol (Cysteamine) dioxygenase. | Glutamate decarboxylase like 1. | 0.937 |
| BAAT | CSAD | ENSPTRP00000089725 | ENSPTRP00000083350 | Bile acid-CoA:amino acid N-acyltransferase. | Cysteine sulfinic acid decarboxylase. | 0.916 |
| BAAT | FMO3 | ENSPTRP00000089725 | ENSPTRP00000002778 | Bile acid-CoA:amino acid N-acyltransferase. | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] | 0.903 |
| BAAT | GAD1 | ENSPTRP00000089725 | ENSPTRP00000021575 | Bile acid-CoA:amino acid N-acyltransferase. | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. | 0.910 |
| BAAT | GAD2 | ENSPTRP00000089725 | ENSPTRP00000092080 | Bile acid-CoA:amino acid N-acyltransferase. | Glutamate decarboxylase 2. | 0.908 |
| BAAT | GADL1 | ENSPTRP00000089725 | ENSPTRP00000093466 | Bile acid-CoA:amino acid N-acyltransferase. | Glutamate decarboxylase like 1. | 0.916 |
| BAAT | GGT5 | ENSPTRP00000089725 | ENSPTRP00000076209 | Bile acid-CoA:amino acid N-acyltransferase. | Gamma-glutamyltransferase 5. | 0.907 |
| CSAD | ADO | ENSPTRP00000083350 | ENSPTRP00000060555 | Cysteine sulfinic acid decarboxylase. | 2-aminoethanethiol (Cysteamine) dioxygenase. | 0.941 |
| CSAD | BAAT | ENSPTRP00000083350 | ENSPTRP00000089725 | Cysteine sulfinic acid decarboxylase. | Bile acid-CoA:amino acid N-acyltransferase. | 0.916 |
| CSAD | FMO3 | ENSPTRP00000083350 | ENSPTRP00000002778 | Cysteine sulfinic acid decarboxylase. | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] | 0.909 |
| CSAD | GAD2 | ENSPTRP00000083350 | ENSPTRP00000092080 | Cysteine sulfinic acid decarboxylase. | Glutamate decarboxylase 2. | 0.784 |
| CSAD | GADL1 | ENSPTRP00000083350 | ENSPTRP00000093466 | Cysteine sulfinic acid decarboxylase. | Glutamate decarboxylase like 1. | 0.901 |
| CSAD | GGT5 | ENSPTRP00000083350 | ENSPTRP00000076209 | Cysteine sulfinic acid decarboxylase. | Gamma-glutamyltransferase 5. | 0.915 |
| CYP2C9 | CYP2D6 | ENSPTRP00000004853 | ENSPTRP00000042793 | Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. | Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyei [...] | 0.466 |
| CYP2C9 | CYP3A4 | ENSPTRP00000004853 | ENSPTRP00000081767 | Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. | Cytochrome P450 family 3 subfamily A member 4. | 0.978 |
| CYP2C9 | FMO3 | ENSPTRP00000004853 | ENSPTRP00000002778 | Cytochrome P450 family 2 subfamily C member 9; Belongs to the cytochrome P450 family. | Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] | 0.939 |
