HMCN1 protein (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

HMCN1

HMCN1 isoform 1. (5635 aa)

Predicted Functional Partners:

ARMS2

0.748

EGFR

0.512

ABCA4

0.504

FRAS1

0.499

CFHR1

0.492

FRK

0.476

RAX2

0.470

CSMD3

0.468

C2

0.460

FILIP1

0.442

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA4	ARMS2	ENSPTRP00000062840	ENSPTRP00000065361	ABCA4 isoform 2.	Age-related maculopathy susceptibility 2.	0.457
ABCA4	HMCN1	ENSPTRP00000062840	ENSPTRP00000002974	ABCA4 isoform 2.	HMCN1 isoform 1.	0.504
ABCA4	RAX2	ENSPTRP00000062840	ENSPTRP00000017466	ABCA4 isoform 2.	Retina and anterior neural fold homeobox protein 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter (By similarity).	0.581
ARMS2	ABCA4	ENSPTRP00000065361	ENSPTRP00000062840	Age-related maculopathy susceptibility 2.	ABCA4 isoform 2.	0.457
ARMS2	C2	ENSPTRP00000065361	ENSPTRP00000076687	Age-related maculopathy susceptibility 2.	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	0.593
ARMS2	CFHR1	ENSPTRP00000065361	ENSPTRP00000044519	Age-related maculopathy susceptibility 2.	T0196413 isoform 1.	0.529
ARMS2	HMCN1	ENSPTRP00000065361	ENSPTRP00000002974	Age-related maculopathy susceptibility 2.	HMCN1 isoform 1.	0.748
C2	ARMS2	ENSPTRP00000076687	ENSPTRP00000065361	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	Age-related maculopathy susceptibility 2.	0.593
C2	CFHR1	ENSPTRP00000076687	ENSPTRP00000044519	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	T0196413 isoform 1.	0.691
C2	HMCN1	ENSPTRP00000076687	ENSPTRP00000002974	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	HMCN1 isoform 1.	0.460
CFHR1	ARMS2	ENSPTRP00000044519	ENSPTRP00000065361	T0196413 isoform 1.	Age-related maculopathy susceptibility 2.	0.529
CFHR1	C2	ENSPTRP00000044519	ENSPTRP00000076687	T0196413 isoform 1.	Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes (By similarity).	0.691
CFHR1	HMCN1	ENSPTRP00000044519	ENSPTRP00000002974	T0196413 isoform 1.	HMCN1 isoform 1.	0.492
CSMD3	HMCN1	ENSPTRP00000035093	ENSPTRP00000002974	CUB and Sushi multiple domains 3.	HMCN1 isoform 1.	0.468
EGFR	FRK	ENSPTRP00000069741	ENSPTRP00000031633	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.612
EGFR	HMCN1	ENSPTRP00000069741	ENSPTRP00000002974	Receptor protein-tyrosine kinase.	HMCN1 isoform 1.	0.512
FILIP1	FRK	ENSPTRP00000031373	ENSPTRP00000031633	Filamin A interacting protein 1.	Tyrosine-protein kinase.	0.457
FILIP1	HMCN1	ENSPTRP00000031373	ENSPTRP00000002974	Filamin A interacting protein 1.	HMCN1 isoform 1.	0.442
FRAS1	HMCN1	ENSPTRP00000046968	ENSPTRP00000002974	Fraser extracellular matrix complex subunit 1.	HMCN1 isoform 1.	0.499
FRK	EGFR	ENSPTRP00000031633	ENSPTRP00000069741	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.612