STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DSTYKDual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types. (930 aa)    
Predicted Functional Partners:
SPINK6
Serine peptidase inhibitor, Kazal type 6.
    
 
 0.916
SPINK14
Serine peptidase inhibitor, Kazal type 14 (putative).
    
 
 0.916
FAM92B
Family with sequence similarity 92 member B.
   
 0.844
OSMR
Oncostatin M receptor.
    
 0.781
RHOH
RHOH isoform 10.
   
 0.704
SIX6
SIX homeobox 6.
      
 0.699
EPOR
Erythropoietin receptor; Receptor for erythropoietin.
    
 0.627
LOC736783
Chymotrypsinogen B2.
    
 0.600
MIB2
Mindbomb homolog 2.
   
 0.541
LIFR
Leukemia inhibitory factor receptor alpha.
    
 0.535
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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