| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACE | ACE2 | ENSPTRP00000038991 | ENSPTRP00000037158 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Angiotensin-converting enzyme. | 0.957 |
| ACE | AGT | ENSPTRP00000038991 | ENSPTRP00000003543 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | 0.997 |
| ACE | AGTR1 | ENSPTRP00000038991 | ENSPTRP00000063456 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.910 |
| ACE | AGTR2 | ENSPTRP00000038991 | ENSPTRP00000073068 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. | 0.680 |
| ACE | BDKRB2 | ENSPTRP00000038991 | ENSPTRP00000086689 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | B2 bradykinin receptor isoform X1. | 0.629 |
| ACE | CLTRN | ENSPTRP00000038991 | ENSPTRP00000084667 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | TMEM27 isoform 1. | 0.509 |
| ACE | ENPEP | ENSPTRP00000038991 | ENSPTRP00000062528 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Aminopeptidase. | 0.937 |
| ACE | MAS1 | ENSPTRP00000038991 | ENSPTRP00000032021 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | MAS1 isoform 1; Belongs to the G-protein coupled receptor 1 family. | 0.508 |
| ACE | REN | ENSPTRP00000038991 | ENSPTRP00000051292 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.991 |
| ACE2 | ACE | ENSPTRP00000037158 | ENSPTRP00000038991 | Angiotensin-converting enzyme. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.957 |
| ACE2 | AGT | ENSPTRP00000037158 | ENSPTRP00000003543 | Angiotensin-converting enzyme. | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | 0.994 |
| ACE2 | AGTR1 | ENSPTRP00000037158 | ENSPTRP00000063456 | Angiotensin-converting enzyme. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.933 |
| ACE2 | AGTR2 | ENSPTRP00000037158 | ENSPTRP00000073068 | Angiotensin-converting enzyme. | Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. | 0.757 |
| ACE2 | BDKRB2 | ENSPTRP00000037158 | ENSPTRP00000086689 | Angiotensin-converting enzyme. | B2 bradykinin receptor isoform X1. | 0.442 |
| ACE2 | ENPEP | ENSPTRP00000037158 | ENSPTRP00000062528 | Angiotensin-converting enzyme. | Aminopeptidase. | 0.535 |
| ACE2 | MAS1 | ENSPTRP00000037158 | ENSPTRP00000032021 | Angiotensin-converting enzyme. | MAS1 isoform 1; Belongs to the G-protein coupled receptor 1 family. | 0.684 |
| ACE2 | REN | ENSPTRP00000037158 | ENSPTRP00000051292 | Angiotensin-converting enzyme. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.989 |
| AGT | ACE | ENSPTRP00000003543 | ENSPTRP00000038991 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.997 |
| AGT | ACE2 | ENSPTRP00000003543 | ENSPTRP00000037158 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Angiotensin-converting enzyme. | 0.994 |
| AGT | AGTR1 | ENSPTRP00000003543 | ENSPTRP00000063456 | Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. | 0.999 |
