STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMYD3SET and MYND domain containing 3. (428 aa)    
Predicted Functional Partners:
MAP3K2
Mitogen-activated protein kinase kinase kinase 2.
   
 
 0.941
HSP90AA1
Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]
   
 
 0.809
ESR1
Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
   
 0.754
CAMKMT
Calmodulin-lysine N-methyltransferase.
     
 0.751
HELZ
Helicase with zinc finger.
    
 0.734
PLOD1
Procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1.
   
 0.714
PLOD3
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3.
   
 0.690
PLOD2
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2.
   
 0.690
PDLIM1
PDZ and LIM domain 1.
   
  
 0.675
NKX2-8
NKX2-8 isoform 1.
    
 
 0.672
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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