STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SVILSVIL isoform 6. (2214 aa)    
Predicted Functional Partners:
CORO6
Coronin; Belongs to the WD repeat coronin family.
   
  
 0.599
CORO1C
Coronin; Belongs to the WD repeat coronin family.
   
  
 0.572
CORO1A
Coronin; Belongs to the WD repeat coronin family.
   
  
 0.500
TLN1
TLN1 isoform 1.
   
  
 0.488
TLN2
TLN2 isoform 1.
   
  
 0.487
AFDN
Afadin, adherens junction formation factor.
      
 0.471
HCLS1
Hematopoietic cell-specific Lyn substrate 1.
      
 0.465
CORO1B
Coronin; Belongs to the WD repeat coronin family.
   
  
 0.441
LOC469572
Lymphotactin.
      
 0.437
AR
Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
    
 
 0.420
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.