STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)    
Predicted Functional Partners:
NFKB1
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.
   
 0.999
TNIP2
TNFAIP3 interacting protein 2.
   
 0.986
MAP2K1
Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...]
  
0.975
MAP3K14
Mitogen-activated protein kinase kinase kinase 14.
    
0.966
MAP2K4
Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.
    
0.964
AKT1
AKT1 isoform 3; Belongs to the protein kinase superfamily.
   
0.952
IKBKB
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.
    
0.950
AKT3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
   
0.949
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
    
0.948
AKT2
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
   
0.948
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.