SGMS1 protein (Pan troglodytes) - STRING interaction network

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Predicted Interactions

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Score

SGMS1

Sphingomyelin synthase 1. (419 aa)

Predicted Functional Partners:

CERS3

0.954

SMPD1

0.952

SMPD2

0.946

SMPD3

0.945

CERS2

0.944

UGCG

0.944

CERS6

0.944

ASAH1

0.943

DEGS1

0.942

SGPP2

0.940

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASAH1	CERS2	ENSPTRP00000063559	ENSPTRP00000040517	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	LAG1 homolog, ceramide synthase 2.	0.948
ASAH1	CERS3	ENSPTRP00000063559	ENSPTRP00000058136	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	CERS3 isoform 1.	0.944
ASAH1	CERS6	ENSPTRP00000063559	ENSPTRP00000067582	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Ceramide synthase 6.	0.954
ASAH1	DEGS1	ENSPTRP00000063559	ENSPTRP00000003391	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Degenerative spermatocyte homolog 1, lipid desaturase.	0.944
ASAH1	SGMS1	ENSPTRP00000063559	ENSPTRP00000004317	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingomyelin synthase 1.	0.943
ASAH1	SGPP2	ENSPTRP00000063559	ENSPTRP00000078528	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingosine-1-phosphate phosphatase 2.	0.930
ASAH1	SMPD1	ENSPTRP00000063559	ENSPTRP00000005756	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.968
ASAH1	SMPD2	ENSPTRP00000063559	ENSPTRP00000031570	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingomyelin phosphodiesterase 2, neutral membrane (Neutral sphingomyelinase).	0.948
ASAH1	SMPD3	ENSPTRP00000063559	ENSPTRP00000014114	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingomyelin phosphodiesterase 3.	0.937
ASAH1	UGCG	ENSPTRP00000063559	ENSPTRP00000065363	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	UDP-glucose ceramide glucosyltransferase.	0.953
CERS2	ASAH1	ENSPTRP00000040517	ENSPTRP00000063559	LAG1 homolog, ceramide synthase 2.	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	0.948
CERS2	CERS3	ENSPTRP00000040517	ENSPTRP00000058136	LAG1 homolog, ceramide synthase 2.	CERS3 isoform 1.	0.902
CERS2	CERS6	ENSPTRP00000040517	ENSPTRP00000067582	LAG1 homolog, ceramide synthase 2.	Ceramide synthase 6.	0.930
CERS2	DEGS1	ENSPTRP00000040517	ENSPTRP00000003391	LAG1 homolog, ceramide synthase 2.	Degenerative spermatocyte homolog 1, lipid desaturase.	0.956
CERS2	SGMS1	ENSPTRP00000040517	ENSPTRP00000004317	LAG1 homolog, ceramide synthase 2.	Sphingomyelin synthase 1.	0.944
CERS2	SGPP2	ENSPTRP00000040517	ENSPTRP00000078528	LAG1 homolog, ceramide synthase 2.	Sphingosine-1-phosphate phosphatase 2.	0.923
CERS2	SMPD1	ENSPTRP00000040517	ENSPTRP00000005756	LAG1 homolog, ceramide synthase 2.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.818
CERS2	SMPD2	ENSPTRP00000040517	ENSPTRP00000031570	LAG1 homolog, ceramide synthase 2.	Sphingomyelin phosphodiesterase 2, neutral membrane (Neutral sphingomyelinase).	0.804
CERS2	SMPD3	ENSPTRP00000040517	ENSPTRP00000014114	LAG1 homolog, ceramide synthase 2.	Sphingomyelin phosphodiesterase 3.	0.776
CERS2	UGCG	ENSPTRP00000040517	ENSPTRP00000065363	LAG1 homolog, ceramide synthase 2.	UDP-glucose ceramide glucosyltransferase.	0.947