| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| A2M | PLAU | ENSPTRP00000056596 | ENSPTRP00000004595 | Alpha-2-macroglobulin. | Plasminogen activator, urokinase. | 0.924 |
| A2M | PLG | ENSPTRP00000056596 | ENSPTRP00000032051 | Alpha-2-macroglobulin. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.637 |
| A2M | SERPINA1 | ENSPTRP00000056596 | ENSPTRP00000042361 | Alpha-2-macroglobulin. | Serpin family A member 1; Belongs to the serpin family. | 0.805 |
| A2M | SERPINA5 | ENSPTRP00000056596 | ENSPTRP00000074881 | Alpha-2-macroglobulin. | Serpin family A member 5; Belongs to the serpin family. | 0.453 |
| A2M | SERPINE1 | ENSPTRP00000056596 | ENSPTRP00000033420 | Alpha-2-macroglobulin. | Serpin family E member 1; Belongs to the serpin family. | 0.419 |
| A2M | SERPING1 | ENSPTRP00000056596 | ENSPTRP00000088468 | Alpha-2-macroglobulin. | Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family. | 0.572 |
| FAH | PLAU | ENSPTRP00000091044 | ENSPTRP00000004595 | Fumarylacetoacetase. | Plasminogen activator, urokinase. | 0.912 |
| PLAU | A2M | ENSPTRP00000004595 | ENSPTRP00000056596 | Plasminogen activator, urokinase. | Alpha-2-macroglobulin. | 0.924 |
| PLAU | FAH | ENSPTRP00000004595 | ENSPTRP00000091044 | Plasminogen activator, urokinase. | Fumarylacetoacetase. | 0.912 |
| PLAU | PLAUR | ENSPTRP00000004595 | ENSPTRP00000054428 | Plasminogen activator, urokinase. | Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity). | 0.999 |
| PLAU | PLG | ENSPTRP00000004595 | ENSPTRP00000032051 | Plasminogen activator, urokinase. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.972 |
| PLAU | SERPINA1 | ENSPTRP00000004595 | ENSPTRP00000042361 | Plasminogen activator, urokinase. | Serpin family A member 1; Belongs to the serpin family. | 0.938 |
| PLAU | SERPINA5 | ENSPTRP00000004595 | ENSPTRP00000074881 | Plasminogen activator, urokinase. | Serpin family A member 5; Belongs to the serpin family. | 0.957 |
| PLAU | SERPINB2 | ENSPTRP00000004595 | ENSPTRP00000070796 | Plasminogen activator, urokinase. | SERPINB10 isoform 4; Belongs to the serpin family. | 0.981 |
| PLAU | SERPINE1 | ENSPTRP00000004595 | ENSPTRP00000033420 | Plasminogen activator, urokinase. | Serpin family E member 1; Belongs to the serpin family. | 0.998 |
| PLAU | SERPINE2 | ENSPTRP00000004595 | ENSPTRP00000022182 | Plasminogen activator, urokinase. | Serpin family E member 2; Belongs to the serpin family. | 0.991 |
| PLAU | SERPING1 | ENSPTRP00000004595 | ENSPTRP00000088468 | Plasminogen activator, urokinase. | Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family. | 0.932 |
| PLAUR | PLAU | ENSPTRP00000054428 | ENSPTRP00000004595 | Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity). | Plasminogen activator, urokinase. | 0.999 |
| PLAUR | PLG | ENSPTRP00000054428 | ENSPTRP00000032051 | Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity). | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.768 |
| PLAUR | SERPINB2 | ENSPTRP00000054428 | ENSPTRP00000070796 | Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity). | SERPINB10 isoform 4; Belongs to the serpin family. | 0.686 |
