STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)    
Predicted Functional Partners:
LLGL2
LLGL scribble cell polarity complex component 2.
    
 0.840
CASK
Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.
   
0.744
SORBS3
Sorbin and SH3 domain containing 3.
   
 
 0.722
NOD2
Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...]
   
  
 0.679
GRIN1
Glutamate receptor, ionotropic, N-methyl D-aspartate 1.
   
 0.627
STX4
STX4 isoform 4; Belongs to the syntaxin family.
     
 0.619
POLR2F
RNA polymerase II subunit F.
  
  
 0.601
ITSN2
ITSN2 isoform 1.
   
 0.589
APRT
Adenine phosphoribosyltransferase.
  
 
 0.568
RND2
Rho family GTPase 2.
   
  0.562
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.