STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (805 aa)    
Predicted Functional Partners:
PIK3R1
Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).
     
 0.967
PIK3R2
Phosphoinositide-3-kinase, regulatory subunit 2 (Beta).
     
 0.948
PIK3R3
Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma).
     
 0.948
PIK3CB
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.
   
 
 0.943
SYK
Tyrosine-protein kinase.
    
 0.935
CD19
CD19 isoform 1.
   
 
 0.841
HACD4
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...]
      
 0.729
ATP5MD
Up-regulated during skeletal muscle growth 5 homolog.
      
 0.718
STRADB
STE20-related kinase adaptor beta.
      
 0.714
ACSS3
Acyl-CoA synthetase short-chain family member 3.
      
 0.687
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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