STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GOT1Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa)    
Predicted Functional Partners:
MDH2
Malate dehydrogenase.
   
 0.986
GOT2
Aspartate aminotransferase.
  
0.976
MDH1
Malate dehydrogenase.
   
 0.968
HPD
4-hydroxyphenylpyruvate dioxygenase.
  
 
 0.963
GPT
Glutamic--pyruvic transaminase.
   
 0.962
LDHAL6A
L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.
   
 0.961
LDHAL6B
L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.
   
 0.961
GPT2
Glutamic pyruvate transaminase (Alanine aminotransferase) 2.
   
 0.960
MPST
Sulfurtransferase.
  
 
 0.960
TST
Sulfurtransferase.
  
 
 0.958
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (30%) [HD]