STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CASP7CASP7 isoform 1; Belongs to the peptidase C14A family. (388 aa)    
Predicted Functional Partners:
XIAP
Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX.
   
 0.998
BIRC2
Baculoviral IAP repeat containing 2.
   
 0.994
CASP8
Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
   
0.985
BIRC7
Baculoviral IAP repeat containing 7.
   
 0.983
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
   
 0.982
BIRC3
Baculoviral IAP repeat containing 3.
   
 0.979
ENSPTRP00000085846
annotation not available
   
 0.976
CASP10
CASP10 isoform 4; Belongs to the peptidase C14A family.
   
0.966
CASP9
CASP9 isoform 4; Belongs to the peptidase C14A family.
    
0.966
CASP3
Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.
  
 
0.964
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.