Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EMX2Empty spiracles homeobox 2. (252 aa)    
Predicted Functional Partners:
PAX2
PAX2 isoform 1.
    
 0.807
FOXG1
FOXG1 isoform 8.
   
 0.795
POLB
DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
    
   0.662
TBR1
T-box brain transcription factor 1.
    
 0.657
LHX1
LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis (By similarity).
    
 0.657
SP8
Sp8 transcription factor.
    
 
 0.619
PAPPA2
PAPPA2 isoform 1.
      
 0.615
CTNNB1
Catenin (Cadherin-associated protein), beta 1, 88kDa.
     
 0.594
LHX5
LHX5 isoform 2.
    
 0.590
GPR156
G protein-coupled receptor 156.
      
 0.589
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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