| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADH1B | ALDH2 | ENSPTRP00000071388 | ENSPTRP00000090308 | All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. | T0055793 isoform 1. | 0.940 |
| ADH1B | ALDH3A1 | ENSPTRP00000071388 | ENSPTRP00000052956 | All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.822 |
| ADH1B | CYP2E1 | ENSPTRP00000071388 | ENSPTRP00000005465 | All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.957 |
| ADH1B | UGT1A3 | ENSPTRP00000071388 | ENSPTRP00000082441 | All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. | UDP-glucuronosyltransferase 1-3 isoform X2. | 0.663 |
| ADH1B | UGT1A5 | ENSPTRP00000071388 | ENSPTRP00000063403 | All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.663 |
| ADH1B | UGT2B7 | ENSPTRP00000071388 | ENSPTRP00000063599 | All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.673 |
| ALDH2 | ADH1B | ENSPTRP00000090308 | ENSPTRP00000071388 | T0055793 isoform 1. | All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. | 0.940 |
| ALDH2 | CYP2E1 | ENSPTRP00000090308 | ENSPTRP00000005465 | T0055793 isoform 1. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.954 |
| ALDH3A1 | ADH1B | ENSPTRP00000052956 | ENSPTRP00000071388 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. | 0.822 |
| ALDH3A1 | CYP2E1 | ENSPTRP00000052956 | ENSPTRP00000005465 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.949 |
| ALDH3A1 | EPHX1 | ENSPTRP00000052956 | ENSPTRP00000003444 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.439 |
| CYP1A2 | CYP2E1 | ENSPTRP00000070670 | ENSPTRP00000005465 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.952 |
| CYP1A2 | CYP3A4 | ENSPTRP00000070670 | ENSPTRP00000081767 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Cytochrome P450 family 3 subfamily A member 4. | 0.963 |
| CYP1A2 | CYP7A1 | ENSPTRP00000070670 | ENSPTRP00000034711 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.964 |
| CYP1A2 | EPHX1 | ENSPTRP00000070670 | ENSPTRP00000003444 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.933 |
| CYP1A2 | UGT1A3 | ENSPTRP00000070670 | ENSPTRP00000082441 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase 1-3 isoform X2. | 0.951 |
| CYP1A2 | UGT1A5 | ENSPTRP00000070670 | ENSPTRP00000063403 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.962 |
| CYP1A2 | UGT2B7 | ENSPTRP00000070670 | ENSPTRP00000063599 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.963 |
| CYP2E1 | ADH1B | ENSPTRP00000005465 | ENSPTRP00000071388 | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal. Catalyzes in the oxidative direction with higher efficiency. Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal. | 0.957 |
| CYP2E1 | ALDH2 | ENSPTRP00000005465 | ENSPTRP00000090308 | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | T0055793 isoform 1. | 0.954 |
