| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IKBKB | IRAK1-2 | ENSPTRP00000034600 | ENSPTRP00000038647 | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. | Interleukin-1 receptor-associated kinase 1. | 0.696 |
| IKBKB | IRAK2 | ENSPTRP00000034600 | ENSPTRP00000025212 | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. | Interleukin-1 receptor-associated kinase 2. | 0.625 |
| IKBKB | MAP3K7 | ENSPTRP00000034600 | ENSPTRP00000057993 | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.996 |
| IKBKB | MYD88 | ENSPTRP00000034600 | ENSPTRP00000061524 | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.674 |
| IKBKB | SQSTM1 | ENSPTRP00000034600 | ENSPTRP00000047790 | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. | SQSTM1 isoform 4. | 0.842 |
| IKBKB | TAB1 | ENSPTRP00000034600 | ENSPTRP00000092424 | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. | 0.979 |
| IKBKB | TAB2 | ENSPTRP00000034600 | ENSPTRP00000031895 | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. | 0.980 |
| IKBKB | TAB3 | ENSPTRP00000034600 | ENSPTRP00000047463 | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. | 0.977 |
| IKBKB | TNFAIP3 | ENSPTRP00000034600 | ENSPTRP00000031827 | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. | Tumor necrosis factor, alpha-induced protein 3. | 0.879 |
| IKBKB | TRAF6 | ENSPTRP00000034600 | ENSPTRP00000006096 | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.998 |
| IRAK1-2 | IKBKB | ENSPTRP00000038647 | ENSPTRP00000034600 | Interleukin-1 receptor-associated kinase 1. | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. | 0.696 |
| IRAK1-2 | IRAK2 | ENSPTRP00000038647 | ENSPTRP00000025212 | Interleukin-1 receptor-associated kinase 1. | Interleukin-1 receptor-associated kinase 2. | 0.986 |
| IRAK1-2 | MAP3K7 | ENSPTRP00000038647 | ENSPTRP00000057993 | Interleukin-1 receptor-associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.987 |
| IRAK1-2 | MYD88 | ENSPTRP00000038647 | ENSPTRP00000061524 | Interleukin-1 receptor-associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.997 |
| IRAK1-2 | SQSTM1 | ENSPTRP00000038647 | ENSPTRP00000047790 | Interleukin-1 receptor-associated kinase 1. | SQSTM1 isoform 4. | 0.897 |
| IRAK1-2 | TAB1 | ENSPTRP00000038647 | ENSPTRP00000092424 | Interleukin-1 receptor-associated kinase 1. | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. | 0.960 |
| IRAK1-2 | TAB2 | ENSPTRP00000038647 | ENSPTRP00000031895 | Interleukin-1 receptor-associated kinase 1. | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. | 0.992 |
| IRAK1-2 | TAB3 | ENSPTRP00000038647 | ENSPTRP00000047463 | Interleukin-1 receptor-associated kinase 1. | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. | 0.976 |
| IRAK1-2 | TNFAIP3 | ENSPTRP00000038647 | ENSPTRP00000031827 | Interleukin-1 receptor-associated kinase 1. | Tumor necrosis factor, alpha-induced protein 3. | 0.407 |
| IRAK1-2 | TRAF6 | ENSPTRP00000038647 | ENSPTRP00000006096 | Interleukin-1 receptor-associated kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.998 |
