close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB2Damage-specific DNA binding protein 2, 48kDa. (427 aa)    
Predicted Functional Partners:
DDB1
Damage-specific DNA binding protein 1, 127kDa.
    
 0.999
RBX1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.992
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.984
CUL4A-2
Cullin 4A.
    
 0.983
CUL4A
CUL4A isoform 5; Belongs to the cullin family.
    
 0.976
CUL4B
CUL4B isoform 3; Belongs to the cullin family.
    
 0.975
COP1
Ring finger and WD repeat domain 2.
    
 0.969
ERCC8
Excision repair cross-complementing rodent repair deficiency, complementation group 8.
    
0.967
USP24
Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family.
    
 0.956
XPC
XPC complex subunit, DNA damage recognition and repair factor.
   
 0.954
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.