| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD14 | CSF1R | ENSPTRP00000068640 | ENSPTRP00000080883 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.706 |
| CD14 | ITGAM | ENSPTRP00000068640 | ENSPTRP00000013737 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Integrin subunit alpha M; Belongs to the integrin alpha chain family. | 0.400 |
| CD14 | SPI1 | ENSPTRP00000068640 | ENSPTRP00000084012 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | Spi-1 proto-oncogene. | 0.919 |
| CSF1R | CD14 | ENSPTRP00000080883 | ENSPTRP00000068640 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] | 0.706 |
| CSF1R | FCGR1A | ENSPTRP00000080883 | ENSPTRP00000002095 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | FCGR1A isoform 2. | 0.489 |
| CSF1R | ITGAM | ENSPTRP00000080883 | ENSPTRP00000013737 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Integrin subunit alpha M; Belongs to the integrin alpha chain family. | 0.633 |
| CSF1R | RUNX1 | ENSPTRP00000080883 | ENSPTRP00000092866 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.960 |
| CSF1R | SPI1 | ENSPTRP00000080883 | ENSPTRP00000084012 | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Spi-1 proto-oncogene. | 0.979 |
| FCGR1A | CSF1R | ENSPTRP00000002095 | ENSPTRP00000080883 | FCGR1A isoform 2. | Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.489 |
| FCGR1A | ITGAM | ENSPTRP00000002095 | ENSPTRP00000013737 | FCGR1A isoform 2. | Integrin subunit alpha M; Belongs to the integrin alpha chain family. | 0.614 |
| FCGR1A | SPI1 | ENSPTRP00000002095 | ENSPTRP00000084012 | FCGR1A isoform 2. | Spi-1 proto-oncogene. | 0.938 |
| FLT3 | GATA2 | ENSPTRP00000009773 | ENSPTRP00000054198 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | GATA binding protein 2. | 0.421 |
| FLT3 | ITGAM | ENSPTRP00000009773 | ENSPTRP00000013737 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Integrin subunit alpha M; Belongs to the integrin alpha chain family. | 0.497 |
| FLT3 | RARA | ENSPTRP00000009773 | ENSPTRP00000053041 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | RARA isoform 4. | 0.493 |
| FLT3 | RUNX1 | ENSPTRP00000009773 | ENSPTRP00000092866 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.570 |
| FLT3 | RUNX1T1 | ENSPTRP00000009773 | ENSPTRP00000075111 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | RUNX1 translocation partner 1. | 0.487 |
| FLT3 | SPI1 | ENSPTRP00000009773 | ENSPTRP00000084012 | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | Spi-1 proto-oncogene. | 0.957 |
| GATA2 | FLT3 | ENSPTRP00000054198 | ENSPTRP00000009773 | GATA binding protein 2. | Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.421 |
| GATA2 | RUNX1 | ENSPTRP00000054198 | ENSPTRP00000092866 | GATA binding protein 2. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.853 |
| GATA2 | SPI1 | ENSPTRP00000054198 | ENSPTRP00000084012 | GATA binding protein 2. | Spi-1 proto-oncogene. | 0.945 |
