STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MACROD1Mono-ADP ribosylhydrolase 1. (325 aa)    
Predicted Functional Partners:
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
    
 
 0.802
ART5
NAD(P)(+)--arginine ADP-ribosyltransferase.
      
 0.802
PARG
Uncharacterized protein.
   
  
 0.800
PARG-2
Poly(ADP-ribose) glycohydrolase.
   
  
 0.800
OARD1
Chromosome 6 open reading frame 130.
    
 
 0.671
ADPRHL2
ADPRHL2 isoform 1.
     
 0.664
H2AFY2
H2AFY2 isoform 1.
  
 
 
 0.624
ESR1
Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
    
 
 0.612
AKT1S1
AKT1 substrate 1 (Proline-rich).
   
  
 0.591
ADPRH
ADP-ribosylarginine hydrolase.
      
 0.576
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (66%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.