STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)    
Predicted Functional Partners:
CASP8
Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
   
 0.999
RIPK1
Receptor (TNFRSF)-interacting serine-threonine kinase 1.
   
 0.999
TRADD
TNFRSF1A-associated via death domain.
   
 0.999
CASP10
CASP10 isoform 4; Belongs to the peptidase C14A family.
   
 0.999
CFLAR
CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family.
    
 0.999
FAS
Fas (TNF receptor superfamily, member 6).
   
 0.999
RIPK3
Receptor interacting serine/threonine kinase 3.
   
 0.998
TNFRSF1A
Tumor necrosis factor receptor superfamily, member 1A.
   
 0.998
TNFRSF10A
Tumor necrosis factor receptor superfamily, member 10a.
    
 0.998
FASLG
FASLG isoform 1; Belongs to the tumor necrosis factor family.
    
 0.990
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.