STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPCS2Signal peptidase complex subunit 2. (257 aa)    
Predicted Functional Partners:
SPCS1
Signal peptidase complex subunit 1.
   
 0.999
SEC11C
Signal peptidase complex catalytic subunit SEC11.
   
 0.999
SPCS3
Signal peptidase complex subunit 3.
   
 0.998
SEC11A
Signal peptidase complex catalytic subunit SEC11.
   
 0.993
GRP
Gastrin releasing peptide.
   
 0.829
ARPC5L
Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
      
 0.784
TMCO1
Transmembrane and coiled-coil domains 1.
   
    0.778
ALPL
Alkaline phosphatase.
   
   0.731
IMMP1L
Mitochondrial inner membrane protease subunit.
   
 0.659
ITFG2
Integrin alpha FG-GAP repeat-containing protein 2.
   
 0.659
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.