ACER3 protein (Pan troglodytes) - STRING interaction network

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Score

ACER3

Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)

Predicted Functional Partners:

ASAH1

0.956

ASAH2

0.950

SPHK1

0.944

CERS6

0.943

CERS2

0.942

SPHK2

0.941

CERS3

0.939

PLPP2

0.933

DEGS1

0.931

CERS4

0.930

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACER3	ASAH1	ENSPTRP00000007035	ENSPTRP00000063559	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	0.956
ACER3	ASAH2	ENSPTRP00000007035	ENSPTRP00000090739	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Neutral ceramidase.	0.950
ACER3	CERS2	ENSPTRP00000007035	ENSPTRP00000040517	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	LAG1 homolog, ceramide synthase 2.	0.942
ACER3	CERS3	ENSPTRP00000007035	ENSPTRP00000058136	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	CERS3 isoform 1.	0.939
ACER3	CERS4	ENSPTRP00000007035	ENSPTRP00000017724	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	CERS4 isoform 1.	0.930
ACER3	CERS6	ENSPTRP00000007035	ENSPTRP00000067582	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Ceramide synthase 6.	0.943
ACER3	DEGS1	ENSPTRP00000007035	ENSPTRP00000003391	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Degenerative spermatocyte homolog 1, lipid desaturase.	0.931
ACER3	PLPP2	ENSPTRP00000007035	ENSPTRP00000017230	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	PLPP2 isoform 5.	0.933
ACER3	SPHK1	ENSPTRP00000007035	ENSPTRP00000052717	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Sphingosine kinase 1.	0.944
ACER3	SPHK2	ENSPTRP00000007035	ENSPTRP00000019290	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Sphingosine kinase 2.	0.941
ASAH1	ACER3	ENSPTRP00000063559	ENSPTRP00000007035	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.956
ASAH1	ASAH2	ENSPTRP00000063559	ENSPTRP00000090739	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Neutral ceramidase.	0.962
ASAH1	CERS2	ENSPTRP00000063559	ENSPTRP00000040517	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	LAG1 homolog, ceramide synthase 2.	0.948
ASAH1	CERS3	ENSPTRP00000063559	ENSPTRP00000058136	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	CERS3 isoform 1.	0.944
ASAH1	CERS4	ENSPTRP00000063559	ENSPTRP00000017724	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	CERS4 isoform 1.	0.938
ASAH1	CERS6	ENSPTRP00000063559	ENSPTRP00000067582	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Ceramide synthase 6.	0.954
ASAH1	DEGS1	ENSPTRP00000063559	ENSPTRP00000003391	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Degenerative spermatocyte homolog 1, lipid desaturase.	0.944
ASAH1	PLPP2	ENSPTRP00000063559	ENSPTRP00000017230	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	PLPP2 isoform 5.	0.919
ASAH1	SPHK1	ENSPTRP00000063559	ENSPTRP00000052717	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingosine kinase 1.	0.964
ASAH1	SPHK2	ENSPTRP00000063559	ENSPTRP00000019290	Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...]	Sphingosine kinase 2.	0.963