PAK1 protein (Pan troglodytes) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

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[Homology]

Score

PAK1

Non-specific serine/threonine protein kinase. (553 aa)

Predicted Functional Partners:

CDC42

0.999

ARHGEF6

0.998

NCK1

0.995

NCK2

0.989

LIMK1-2

0.971

FLNA

0.965

LIMK2

0.949

PAK3

0.949

RAC1

0.946

RAC1-2

0.946

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF6	CDC42	ENSPTRP00000043151	ENSPTRP00000077648	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Cell division cycle 42 (GTP binding protein, 25kDa).	0.916
ARHGEF6	NCK1	ENSPTRP00000043151	ENSPTRP00000026594	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Cytoplasmic protein.	0.837
ARHGEF6	NCK2	ENSPTRP00000043151	ENSPTRP00000021097	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Cytoplasmic protein.	0.713
ARHGEF6	PAK1	ENSPTRP00000043151	ENSPTRP00000007058	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Non-specific serine/threonine protein kinase.	0.998
ARHGEF6	PAK3	ENSPTRP00000043151	ENSPTRP00000062580	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...]	0.995
ARHGEF6	RAC1	ENSPTRP00000043151	ENSPTRP00000068561	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1).	0.596
ARHGEF6	RAC1-2	ENSPTRP00000043151	ENSPTRP00000084384	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	Rac family small GTPase 1.	0.596
CDC42	ARHGEF6	ENSPTRP00000077648	ENSPTRP00000043151	Cell division cycle 42 (GTP binding protein, 25kDa).	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	0.916
CDC42	FLNA	ENSPTRP00000077648	ENSPTRP00000063420	Cell division cycle 42 (GTP binding protein, 25kDa).	FLNA isoform 8.	0.805
CDC42	LIMK1-2	ENSPTRP00000077648	ENSPTRP00000079435	Cell division cycle 42 (GTP binding protein, 25kDa).	LIM domain kinase 1.	0.663
CDC42	LIMK2	ENSPTRP00000077648	ENSPTRP00000049722	Cell division cycle 42 (GTP binding protein, 25kDa).	LIMK2 isoform 6.	0.570
CDC42	NCK1	ENSPTRP00000077648	ENSPTRP00000026594	Cell division cycle 42 (GTP binding protein, 25kDa).	Cytoplasmic protein.	0.817
CDC42	NCK2	ENSPTRP00000077648	ENSPTRP00000021097	Cell division cycle 42 (GTP binding protein, 25kDa).	Cytoplasmic protein.	0.536
CDC42	PAK1	ENSPTRP00000077648	ENSPTRP00000007058	Cell division cycle 42 (GTP binding protein, 25kDa).	Non-specific serine/threonine protein kinase.	0.999
CDC42	PAK3	ENSPTRP00000077648	ENSPTRP00000062580	Cell division cycle 42 (GTP binding protein, 25kDa).	Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...]	0.997
CDC42	RAC1	ENSPTRP00000077648	ENSPTRP00000068561	Cell division cycle 42 (GTP binding protein, 25kDa).	Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1).	0.589
CDC42	RAC1-2	ENSPTRP00000077648	ENSPTRP00000084384	Cell division cycle 42 (GTP binding protein, 25kDa).	Rac family small GTPase 1.	0.590
FLNA	CDC42	ENSPTRP00000063420	ENSPTRP00000077648	FLNA isoform 8.	Cell division cycle 42 (GTP binding protein, 25kDa).	0.805
FLNA	PAK1	ENSPTRP00000063420	ENSPTRP00000007058	FLNA isoform 8.	Non-specific serine/threonine protein kinase.	0.965
FLNA	PAK3	ENSPTRP00000063420	ENSPTRP00000062580	FLNA isoform 8.	Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...]	0.512