BIRC2 protein (Pan troglodytes) - STRING interaction network

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Score

BIRC2

Baculoviral IAP repeat containing 2. (618 aa)

Predicted Functional Partners:

TRAF2

0.999

TRADD

0.999

TNFRSF1A

0.999

RIPK1

0.998

TRAF3

0.997

DIABLO

0.996

CASP3

0.995

TNF

0.995

CASP9

0.995

CASP7

0.994

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC2	CASP3	ENSPTRP00000007251	ENSPTRP00000054330	Baculoviral IAP repeat containing 2.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	0.995
BIRC2	CASP7	ENSPTRP00000007251	ENSPTRP00000074501	Baculoviral IAP repeat containing 2.	CASP7 isoform 1; Belongs to the peptidase C14A family.	0.994
BIRC2	CASP9	ENSPTRP00000007251	ENSPTRP00000089496	Baculoviral IAP repeat containing 2.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.995
BIRC2	DIABLO	ENSPTRP00000007251	ENSPTRP00000071257	Baculoviral IAP repeat containing 2.	Diablo, IAP-binding mitochondrial protein.	0.996
BIRC2	RIPK1	ENSPTRP00000007251	ENSPTRP00000030180	Baculoviral IAP repeat containing 2.	Receptor (TNFRSF)-interacting serine-threonine kinase 1.	0.998
BIRC2	TNF	ENSPTRP00000007251	ENSPTRP00000069905	Baculoviral IAP repeat containing 2.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.995
BIRC2	TNFRSF1A	ENSPTRP00000007251	ENSPTRP00000066030	Baculoviral IAP repeat containing 2.	Tumor necrosis factor receptor superfamily, member 1A.	0.999
BIRC2	TRADD	ENSPTRP00000007251	ENSPTRP00000046129	Baculoviral IAP repeat containing 2.	TNFRSF1A-associated via death domain.	0.999
BIRC2	TRAF2	ENSPTRP00000007251	ENSPTRP00000036949	Baculoviral IAP repeat containing 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
BIRC2	TRAF3	ENSPTRP00000007251	ENSPTRP00000011503	Baculoviral IAP repeat containing 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.997
CASP3	BIRC2	ENSPTRP00000054330	ENSPTRP00000007251	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Baculoviral IAP repeat containing 2.	0.995
CASP3	CASP7	ENSPTRP00000054330	ENSPTRP00000074501	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CASP7 isoform 1; Belongs to the peptidase C14A family.	0.964
CASP3	CASP9	ENSPTRP00000054330	ENSPTRP00000089496	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	CASP9 isoform 4; Belongs to the peptidase C14A family.	0.996
CASP3	DIABLO	ENSPTRP00000054330	ENSPTRP00000071257	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Diablo, IAP-binding mitochondrial protein.	0.796
CASP3	RIPK1	ENSPTRP00000054330	ENSPTRP00000030180	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Receptor (TNFRSF)-interacting serine-threonine kinase 1.	0.785
CASP3	TNF	ENSPTRP00000054330	ENSPTRP00000069905	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.828
CASP3	TNFRSF1A	ENSPTRP00000054330	ENSPTRP00000066030	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily, member 1A.	0.688
CASP3	TRADD	ENSPTRP00000054330	ENSPTRP00000046129	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	TNFRSF1A-associated via death domain.	0.670
CASP3	TRAF2	ENSPTRP00000054330	ENSPTRP00000036949	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.498
CASP3	TRAF3	ENSPTRP00000054330	ENSPTRP00000011503	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.513